Dermatomyositis as a presentation of neuromyelitis optica spectrum disorder

被引：11

作者：

Delman, David ^{[1
]}

Peng, Xianming ^{[1
]}

Zedek, Daniel C. ^{[2
]}

Jewells, Valerie ^{[3
]}

Chahin, Nizar ^{[1
]}

Markovic-Plese, Silva ^{[1
,4
]}

机构：

[1] Dept Neurol, Chapel Hill, NC 27599 USA

[2] Dept Dermatol, Chapel Hill, NC 27599 USA

[3] Dept Radiol, Chapel Hill, NC 27514 USA

[4] Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 278卷

关键词：

Neuromyelitis optica; Dermatomyositis; MDA5; antibody; INTERSTITIAL LUNG-DISEASE; MYOSITIS; AUTOANTIBODIES; INSIGHTS; CANCER;

D O I：

10.1016/j.jneuroim.2014.07.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Importance: This is the first report of neuromyelitis optica spectrum disorder (NMOSD) associated with dermatomyositis (DM). Report: A 40 year-old Caucasian female presented with 6 months of worsening fatigue, rash, acute weakness worse in her lower extremities, and urinary retention. She was found to have both NMOSD and anti-melanoma differentiation-associated gene (MDA)5 positive DM with interstitial lung disease (ILD). She was treated aggressively and she regained her ability to ambulate. Conclusion: We recommend considering NMOSD in the differential diagnosis of patients with DM and other autoimmune disorders that also present with clinical signs of myelopathy. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：108 / 111

页数：4

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