Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury

被引：88
|
作者：
Satake, K
Matsuyama, Y
Kamiya, M
Kawakami, H
Iwata, H
Adachi, K
Kiuchi, K [1 ]
机构：
[1] Nagoya Univ, Sch Med, Dept Orthopaed Surg, Nagoya, Aichi 4668550, Japan
[2] RIKEN, Biomimet Control Res Program, Lab Genes Motor Syst, Moriyama Ku, Nagoya, Aichi 4630003, Japan
[3] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan
来源：
NEUROREPORT | 2000年 / 11卷 / 17期
关键词：
glial cell line-derived neurotrophic factor; macrophage; microglia; rat; spinal cord injury; weight drop technique;
D O I：
10.1097/00001756-200011270-00054
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated the temporal and spatial expression patterns of the GDNF gene after subjecting rats to an acute contusion injury of the spinal cord using the weight drop technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that GDNF transcription in the spinal cord began to increase within 30 min after injury and peaked within 3 h. Immunohistochemical analysis showed GDNF immunoreactivity to be present mainly in microglia and macrophages 1 day after injury,but not in neurons or astrocytes. This immediate upregulation of GDNF gene expression may be a component of an inflammatory process and probably exerts a protective effect on neurons following spinal cord injury (SCI). NeuroReport 11:3877-3881 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：3877 / 3881
页数：5
相关论文
共 50 条
  • [1] History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair
    Walker, Melissa J.
    Xu, Xiao-Ming
    BRAIN SCIENCES, 2018, 8 (06):
  • [2] The Effects of Glial Cell Line-Derived Neurotrophic Factor after Spinal Cord Injury
    Rosich, Konstantin
    Hanna, Bishoy F.
    Ibrahim, Rami K.
    Hellenbrand, Daniel J.
    Hanna, Amgad
    JOURNAL OF NEUROTRAUMA, 2017, 34 (24) : 3311 - 3325
  • [3] Up-regulation of glial cell line-derived neurotrophic factor (GDNF) expression in regenerating muscle fibers in neuromuscular diseases
    Suzuki, H
    Hase, A
    Kim, BY
    Miyata, Y
    Nonaka, I
    Arahata, K
    Akazawa, C
    NEUROSCIENCE LETTERS, 1998, 257 (03) : 165 - 167
  • [4] A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury
    Iannotti, C
    Zhang, YP
    Shields, CB
    Han, YC
    Burke, DA
    Xu, XM
    EXPERIMENTAL NEUROLOGY, 2004, 189 (02) : 317 - 332
  • [5] Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury
    Cheng, H
    Wu, JP
    Tzeng, SF
    JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 69 (03) : 397 - 405
  • [6] Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatum
    Liberatore, GT
    Wong, JYF
    Porritt, MJ
    Donnan, GA
    Howells, DW
    NEUROREPORT, 1997, 8 (14) : 3097 - 3101
  • [7] Upregulation of glial cell line-derived neurotrophic factor (GDNF) in the rat cochlea following noise
    Nam, YJ
    Stöver, T
    Hartman, SS
    Altschuler, RA
    HEARING RESEARCH, 2000, 146 (1-2) : 1 - 6
  • [8] Gene transfer of glial cell line-derived neurotrophic factor promotes functional recovery following spinal cord contusion
    Tai, MH
    Cheng, H
    Wu, JP
    Liu, YL
    Lin, PR
    Kuo, JS
    Tseng, CJ
    Tzeng, SF
    EXPERIMENTAL NEUROLOGY, 2003, 183 (02) : 508 - 515
  • [9] Exogenous administration of glial cell line-derived neurotrophic factor improves recovery after spinal cord injury
    Kao, Cheng-Hsing
    Chen, Sheng-Hsien
    Chio, Chung-Ching
    Chang, Chen-Kuei
    Lin, Mao-Tsun
    RESUSCITATION, 2008, 77 (03) : 395 - 400
  • [10] Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia
    Williams, H. J.
    Norton, N.
    Peirce, T.
    Dwyer, S.
    Williams, N. M.
    Moskvina, V.
    Owen, M. J.
    O'Donovan, M. C.
    SCHIZOPHRENIA RESEARCH, 2007, 97 (1-3) : 271 - 276
12345