Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer

被引:43
|
作者
Ytting, H
Christensen, IJ
Jensenius, JC
Thiel, S
Nielsen, HJ
机构
[1] Hvidovre Univ Hosp, Dept Surg Gastroenterol 435, DK-2650 Hvidovre, Denmark
[2] Aarhus Univ, Inst Med Microbiol & Immunol, DK-8000 Aarhus, Denmark
关键词
colorectal cancer; complement; infectious complications; MBL; prognosis; survival;
D O I
10.1007/s00262-004-0594-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate ( 1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and ( 2) the role of MBL in acute phase response compared to C-reactive protein (CRP). Methods: Preoperative MBL concentration, MBL-associated serine protease (MBL/MASP) activity and CRP were determined in serum from 611 patients and 150 healthy controls. The patients were observed for 8 years. Postoperative infections, recurrence and survival were recorded. Results: The MBL pathway components were increased in the patients compared with the healthy controls (p< 0.0001). Low MBL levels were predictive of pneumonia ( p = 0.01), and pneumonia (n = 87) was associated with poor survival (p = 0.003; HR = 1.5; 95% CI, 1.1 to 1.9). MBL and MBL/MASP activity showed no correlation with CRP ( Spearman's rho = 0.02; 95% CI, - 0.06 to 0.10). Conclusion: Low preoperative MBL levels are predictive of pneumonia, which is associated with poorer survival. MBL concentration and MBL/MASP activity was not predictive of other postoperative infections or long-term prognosis, and showed no correlation with CRP.
引用
收藏
页码:265 / 272
页数:8
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