Withanone-Rich Combination of Ashwagandha Withanolides Restricts Metastasis and Angiogenesis through hnRNP-K

被引：53

作者：

Gao, Ran ^{[1
,2
]}

Shah, Navjot ^{[1
,2
]}

Lee, Jung-Sun ^{[3
]}

Katiyar, Shashank P. ^{[4
]}

Li, Ling ^{[1
,2
]}

Oh, Eonju ^{[3
]}

Sundar, Durai ^{[4
]}

Yun, Chae-Ok ^{[3
]}

Wadhwa, Renu ^{[1
,2
]}

Kaul, Sunil C. ^{[1
,2
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, AIST, Cell Proliferat Res Grp, Tsukuba, Ibaraki 3058562, Japan

[2] Natl Inst Adv Ind Sci & Technol, AIST, DBT, Int Lab Adv Biomed, Tsukuba, Ibaraki 3058562, Japan

[3] Hanyang Univ, Coll Engn, Dept Bioengn, Seoul 133791, South Korea

[4] Indian Inst Technol, Dept Biochem Engn & Biotechnol, New Delhi, India

来源：

MOLECULAR CANCER THERAPEUTICS | 2014年 / 13卷 / 12期

关键词：

NUCLEAR RIBONUCLEOPROTEIN K; BREAST-CANCER CELLS; GROWTH-FACTOR VEGF; MATRIX METALLOPROTEINASES; MOLECULAR-DYNAMICS; ENDOTHELIAL-CELLS; SIGNALING PATHWAY; LEAF EXTRACT; WITHAFERIN; ACTIVATION;

D O I：

10.1158/1535-7163.MCT-14-0324

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ashwagandha is an important herb used in the Indian system of traditional home medicine, Ayurveda. Alcoholic extract (i-Extract) from its leaves and its component, withanone, were previously shown to possess anticancer activity. In the present study, we developed a combination of withanone and withaferin A, major withanolides in the i-Extract, that retained the selective cancer cell killing activity and found that it also has significant antimigratory, -invasive, and -angiogenic activities, in both in vitro and in vivo assays. Using bioinformatics and biochemical approaches, we demonstrate that these phytochemicals caused downregulation of migration-promoting proteins hnRNP-K, VEGF, and metalloproteases and hence are candidate natural drugs for metastatic cancer therapy. (C)2014 AACR.

引用

页码：2930 / 2940

页数：11

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