The Alzheimer's Disease Neuroimaging Initiative: Annual change in biomarkers and clinical outcomes

被引：83

作者：

Beckett, Laurel A. ^{[1
]}

Harvey, Danielle J. ^{[1
]}

Gamst, Anthony ^{[2
]}

Donohue, Michael ^{[2
]}

Kornak, John ^{[3
,4
]}

Zhang, Hao ^{[1
]}

Kuo, Julie H. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA

[2] Univ Calif San Diego, Div Biostat & Bioinformat, San Diego, CA 92103 USA

[3] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

来源：

ALZHEIMERS & DEMENTIA | 2010年 / 6卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; Cerebrospinal fluid; Neuroimaging; FDG PET; MRI; Biomarkers; Clinical trial design; Mild cognitive impairment; Cognitive decline; MILD COGNITIVE IMPAIRMENT; CONVERSION; CORE;

D O I：

10.1016/j.jalz.2010.03.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The Alzheimer's Disease Neuroimaging Initiative Phase 1 (ADNI-1) is a molt site prospective study designed to examine potential cerebrospinal fluid and imaging markers of Alzheimer's disease (AD) and their relationship to cognitive change The objective of this study was to provide a global summary of the overall results and patterns of change observed m candidate markets and clinical measures over the first 2 years of follow-up Methods: Change was summarized for 210 normal controls, 357 mild cognitive impairment. and 162 AD subjects. with baseline and at least one cognitive follow-up assessment Repeated measures and survival models were used to assess baseline biomarker levels as predictors Potential for improving clinical trials was assessed by comparison of precision of markers for capturing change in hypothetical trial designs Results: The first 12 months of complete data on ADNI participants demonstrated the potential for substantial advances in characterizing trajectories of change in a range of biomarkers and clinical outcomes, examining their relationship and timing. and assessing the potential for improvements in clinical trial design Reduced metabolism and greater brain atrophy in the mild cognitive impairment at baseline ale associated with mole rapid cognitive decline and a higher rate of conversion to AD. Use of biomarkers as study entry criteria or as outcomes could reduce the number of participants requited for clinical trials Conclusions: Analyses and comparisons of ADNI data strongly support the hypothesis that measurable change occurs in cerebiospinal fluid. position emission tomography. and magnetic resonance imaging well in advance of the actual diagnosis of AD (C) 2010 The Alzheimer's Association All rights reserved

引用

页码：257 / 264

页数：8

共 29 条

[11] Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: implications for sequence of pathological events in Alzheimers disease [J].

Jack, Clifford R., Jr. ;

Lowe, Val J. ;

Weigand, Stephen D. ;

Wiste, Heather J. ;

Senjem, Matthew L. ;

Knopman, David S. ;

Shiung, Maria M. ;

Gunter, Jeffrey L. ;

Boeve, Bradley F. ;

Kemp, Bradley J. ;

Weiner, Michael ;

Petersen, Ronald C. .

BRAIN, 2009, 132 :1355-1365

[12] Relationships between biomarkers in aging and dementia [J].

Jagust, W. J. ;

Landau, S. M. ;

Shaw, L. M. ;

Trojanowski, J. Q. ;

Koeppe, R. A. ;

Reiman, E. M. ;

Foster, N. L. ;

Petersen, R. C. ;

Weiner, M. W. ;

Price, J. C. ;

Mathis, C. A. .

NEUROLOGY, 2009, 73 (15) :1193-1199

[13]

Killiany RJ, 2000, ANN NEUROL, V47, P430, DOI 10.1002/1531-8249(200004)47:4<430::AID-ANA5>3.0.CO

[14]

2-I

[15] Neuropathology of cognitively normal elderly [J].

Knopman, DS ;

Parisi, JE ;

Salviati, A ;

Floriach-Robert, M ;

Boeve, BF ;

Ivnik, RJ ;

Smith, GE ;

Dickson, DW ;

Johnson, KA ;

Petersen, LE ;

McDonald, WC ;

Braak, H ;

Petersen, RC .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2003, 62 (11) :1087-1095

[16] RANDOM-EFFECTS MODELS FOR LONGITUDINAL DATA [J].

LAIRD, NM ;

WARE, JH .

BIOMETRICS, 1982, 38 (04) :963-974

[17]

LANDAU SM, 2009, NEUROBIOL AGING, V32, P1207

[18] The Alzheimer's disease neuroimaging initiative [J].

Mueller, SG ;

Weiner, MW ;

Thal, LJ ;

Petersen, RC ;

Jack, C ;

Jagust, W ;

Trojanowski, JQ ;

Toga, AW ;

Beckett, L .

NEUROIMAGING CLINICS OF NORTH AMERICA, 2005, 15 (04) :869-+

[19]

Mueller Susanne G, 2005, Alzheimers Dement, V1, P55, DOI 10.1016/j.jalz.2005.06.003

[20] Conversion of amyloid positive and negative MCI to AD over 3 years An 11C-PIB PET study [J].

Okello, A. ;

Koivunen, J. ;

Edison, P. ;

Archer, H. A. ;

Turkheimer, F. E. ;

Nagren, K. ;

Bullock, R. ;

Walker, Z. ;

Kennedy, A. ;

Fox, N. C. ;

Rossor, M. N. ;

Rinne, J. O. ;

Brooks, D. J. .

NEUROLOGY, 2009, 73 (10) :754-760

← 1 2 3 →