Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?

被引：21

作者：

Leone, Vanessa A. ^{[1
]}

Cham, Candace M. ^{[1
]}

Chang, Eugene B. ^{[1
]}

机构：

[1] Univ Chicago, Dept Med Gastroenterol Hepatol & Nutr, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2014年 / 31卷

基金：

美国国家卫生研究院;

关键词：

ARYL-HYDROCARBON RECEPTOR; CD4(+) T-CELLS; CROHNS-DISEASE; INTESTINAL INFLAMMATION; HELICOBACTER-HEPATICUS; ULCERATIVE-COLITIS; SCID MICE; DEPENDENT MECHANISM; HYDROGEN-SULFIDE; TWIN COHORT;

D O I：

10.1016/j.coi.2014.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune disorders, particularly inflammatory bowel diseases (IBD), are increasing at an alarming frequency. While the exact cause remains elusive, studies have examined how the immune system is shaped in the context of genetic susceptibility, gut microbes, and environmental pressures, including dietary intake. Shifts towards a Westernized high fat, high carbohydrate diet result in changes to gut microbiota structure and function that may aid in triggering and perpetuating autoimmunity by promoting the emergence of pathobionts leading to altered immune activation. This review summarizes our current understanding of dietary-induced changes in gut microbiota on autoimmunity in the context of IBD. We provide a framework for leveraging this knowledge to develop new dietary, microbial and immune-based modulation strategies for individualized risk assessment and improving clinical outcomes.

引用

页码：16 / 23

页数：8

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