Ebola vaccine development: Systematic review of pre-clinical and clinical studies, and meta-analysis of determinants of antibody response variability after vaccination

被引：24

作者：

Gross, Lise ^{[2
,3
]}

Lhomme, Edouard ^{[1
,2
,3
,4
]}

Pasin, Chloe ^{[1
,2
,3
]}

Richert, Laura ^{[1
,2
,3
,4
]}

Thiebaut, Rodolphe ^{[1
,2
,3
,4
]}

机构：

[1] Univ Bordeaux, INSERM, UMR 1219, Bordeaux Populat Hlth Res Ctr,ISPED, F-33000 Bordeaux, France

[2] INRIA, Res Ctr, SISTM Team Stat Syst Biol & Translat Med, F-33000 Bordeaux, France

[3] VRI, F-94000 Creteil, France

[4] CHU Bordeaux, Pole Sante Publ, F-33000 Bordeaux, France

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2018年 / 74卷

基金：

欧盟地平线“2020”;

关键词：

Ebola; Vaccine; Review; Meta-analysis; Humans; Nonhuman primates; PROTECTS NONHUMAN-PRIMATES; RESPIRATORY-TRACT IMMUNIZATION; PLACEBO-CONTROLLED TRIAL; VIRUS-VECTORED VACCINE; DOUBLE-BLIND; HEALTHY-ADULTS; MARBURG VIRUS; LETHAL EBOLA; AEROSOL CHALLENGE; ADENOVIRUS VECTOR;

D O I：

10.1016/j.ijid.2018.06.022

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: For Ebola vaccine development, antibody response is a major endpoint although its determinants are not well known. We aimed to review Ebola vaccine studies and to assess factors associated with antibody response variability in humans. Methods: We searched PubMed and Scopus for preventive Ebola vaccine studies in humans or nonhuman primates (NHP), published up to February 2018. For each vaccination group with Ebola Zaire antibody titre measurements after vaccination, data about antibody response and its potential determinants were extracted. A random-effects meta-regression was conducted including human groups with at least 8 individuals. Results: We reviewed 49 studies (202 vaccination groups including 74 human groups) with various vaccine platforms and antigen inserts. Mean antibody titre was slightly higher in NHP (3.10, 95% confidence interval [293; 327]) than in humans (2.75 [257; 293]). Vaccine platform (p < 0.001) and viral strain used for antibody detection (p < 0.001) were associated with antibody response in humans, but adjusted heterogeneity remained at 95%. Conclusions: Various platforms have been evaluated in humans, including Ad26, Ad5, ChimpAd3, DNA, MVA, and VSV. In addition to platforms, viral strain used for antibody detection influences antibody response. However, variability remained mostly unexplained. Therefore, comparison of vaccine immunogenicity needs randomised controlled trials. (c) 2018 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：83 / 96

页数：14

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