LncRNA ELF3-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma

被引:20
|
作者
Chen, Tianming [1 ,2 ]
Zhu, Changhao [3 ]
Wang, Xing [2 ]
Pan, Yaozhen [2 ]
机构
[1] Nanjing Univ, Sch Med, Gulou Hosp, Dept Gen Surg, Nanjing 210008, Jiangsu, Peoples R China
[2] Guizhou Med Univ, Affiliated Canc Hosp, Guiyang 550001, Guizhou, Peoples R China
[3] Guizhou Med Univ, Coll Clin Med, Guiyang 550000, Guizhou, Peoples R China
基金
中国国家自然科学基金;
关键词
CELL-PROLIFERATION; EXPRESSION; DIAGNOSIS; CANCER;
D O I
10.1155/2021/8323487
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background. Expression of long noncoding RNA (lncRNA) ELF3 antisense RNA 1 (ELF3-AS1) is observed in some cancers, while its role in hepatocellular carcinoma (HCC) is unclear. The study aimed to investigate the relationship between ELF3-AS1 and HCC based on database, bioinformatics, and statistical analysis. Methods. In this study, Kruskal-Wallis test, Wilcoxon sign-rank test, logistic regression, Kaplan-Meier method, Cox regression analysis, gene set enrichment analysis (GSEA), and immunoinfiltration analysis were used to assess the relationship between ELF3-AS1 expression and clinical characteristics of HCC patients, the relationship between ELF3-AS1 expression and prognosis of HCC patients, and the possible functions of ELF3-AS1 in HCC. Results. High expression of ELF3-AS1 in patients with HCC was related to T stage (P < 0.001), gender (P = 0.006), residual tumor (P = 0.008), histologic grade (P < 0.001), adjacent hepatic tissue inflammation (P = 0.011), AFP (P < 0.001), and vascular invasion (P = 0.028). High ELF3-AS1 expression was associated with poor overall survival (OS) (P = 0.001) and DSS (P = 0.047). ELF3-AS1 expression (P = 0.011) was independently correlated with OS in HCC patients. In the high ELF3-AS1 expression group, GPCR-radioligand binding, M phase, Class A/1 (rhodopsin-like receptors), cell cycle checkpoints, translation, mitotic metaphase and anaphase, signaling by robo receptors, keratinization, and rRNA processing were differentially enriched by GESA. ELF3-AS1 expression was associated with immune infiltrating cells. Conclusions. ELF3-AS1 expression was associated with poor prognosis in HCC. ELF3-AS1 expression was significantly associated with immune infiltration. ELF3-AS1 is a promising biomarker that can be used for the diagnosis and prognosis of HCC.
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页数:12
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