Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles

被引：22

作者：

Li, Shijie ^{[1
]}

Zhang, Daqi ^{[1
]}

Sheng, Shihou ^{[2
]}

Sun, Hui ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Dept Thyroid Surg, 126 Xiantai St, Changchun 130000, Jilin, Peoples R China

[2] Jilin Univ, China Japan Union Hosp, Dept Gastrointestinal Colorectal & Anal Surg, Changchun, Jilin, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2017年 / 12卷

关键词：

thyroid cancer; silicon dioxide nanoparticle; doxorubicin; acid-triggered release; DRUG-DELIVERY; MESOPOROUS SILICA; ANTICANCER DRUGS; TUMOR SIZE; PH; CARDIOTOXICITY; CARCINOMA; THERAPY; GLAND; NANOCOMPOSITES;

D O I：

10.2147/IJN.S137335

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Currently, therapy for thyroid cancer mainly involves surgery and radioiodine therapy. However, chemotherapy can be used in advanced and aggressive thyroid cancer that cannot be treated by other options. Nevertheless, a major obstacle to the successful treatment of thyroid cancer is the delivery of drugs to the thyroid gland. Here, we present an example of the construction of silicon dioxide nanoparticles with thyroid-stimulating-hormone receptor-targeting ligand that can specifically target the thyroid cancer. Doxorubicin nanoparticles can be triggered by acid to release the drug payload for cancer therapy. These nanoparticles shrink the tumor size in vivo with less toxic side effects. This research paves the way toward effective chemotherapy for thyroid cancer.

引用

页码：5993 / 6003

页数：11

共 42 条

[1] Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation [J].