Potential contribution of insecticide exposure and development of obesity and type 2 diabetes

被引：55

作者：

Xiao, Xiao ^{[1
]}

Clark, John M. ^{[2
]}

Park, Yeonhwa ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Food Sci, Amherst 102 Holdsworth Way, Amherst, MA 01003 USA

[2] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2017年 / 105卷

关键词：

Insecticide; Obesity; Glucose metabolism; Type; 2; diabetes; PERSISTENT ORGANIC POLLUTANTS; ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; INCREASED OXIDATIVE STRESS; GROWTH-FACTOR-I; INSULIN-RESISTANCE; ORGANOCHLORINE PESTICIDES; ACUTE-PANCREATITIS; MITOCHONDRIAL DYSFUNCTION; SUBCHRONIC EXPOSURE;

D O I：

10.1016/j.fct.2017.05.003

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The introduction of insecticides has greatly improved agricultural productivity and human nutrition; however, the wide use of insecticides has also sparked growing concern over their health impacts. Increased rate of cancers, neurodegenerative disorders, reproductive dysfunction, birth defects, respiratory diseases, cardiovascular diseases and aging have been linked with insecticide exposure. Meanwhile, a growing body of evidence is suggesting that exposure to insecticides can also potentiate the risk of obesity and type 2 diabetes. This review summarizes the relationship between insecticide exposure and development of obesity and type 2 diabetes using epidemiological and rodent animal studies, including potential mechanisms. The evidence as a whole suggests that exposure to insecticides is linked to increased risk of obesity and type 2 diabetes. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：456 / 474

页数：19

共 216 条

[1] Abdollahi M, 2004, MED SCI MONITOR, V10, pRA141
[2] Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following subchronic exposure to malathion
Abdollahi, M
Mostafalou, S
Pournourmohammadi, S
Shadnia, S
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2004, 137 (01): : 29 - 34
[3] Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion
Abdollahi, M
Donyavi, M
Pournourmohammadi, S
Saadat, M
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2004, 137 (04): : 343 - 347
[4] Increasing intracellular cAMP and cGMP inhibits cadmium-induced oxidative stress in rat submandibular saliva
Abdollahi, M
Bahreini-Moghadam, A
Emami, B
Fooladian, F
Zafari, K
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2003, 135 (03): : 331 - 336
[5] Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin
Abdollahi, M
Chan, TS
Subrahmanyam, V
O'Brien, PJ
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2003, 252 (1-2) : 205 - 211
[6] Mitochondrial Dysfunction, Insulin Resistance, and Type 2 Diabetes Mellitus
Abdul-Ghani, Muhammad A.
DeFronzo, Ralph A.
[J]. CURRENT DIABETES REPORTS, 2008, 8 (03) : 173 - 178
[7] Organophosphorus ester-induced chronic neurotoxicity
Abou-Donia, MB
[J]. ARCHIVES OF ENVIRONMENTAL HEALTH, 2003, 58 (08): : 484 - 497
[8] ADA,, 2013, COST DIAB
[9] Insulin-like growth factor-1 deficiency and metabolic syndrome
Aguirre, G. A.
Rodriguez De Ita, J.
de la Garza, R. G.
Castilla-Cortazar, I.
[J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2016, 14
[10] Association Between Type 2 Diabetes and Exposure to Persistent Organic Pollutants
Airaksinen, Riikka
Rantakokko, Panu
Eriksson, Johan G.
Blomstedt, Paul
Kajantie, Eero
Kiviranta, Hannu
[J]. DIABETES CARE, 2011, 34 (09) : 1972 - 1979

← 1 2 3 4 5 6 7 8 9 10 →