Synthesis of new polysubstituted piperazines and dihydro-2H-pyrazines by selective reduction of 2-oxo-piperazines

被引：6

作者：

Reginato, Gianna ^{[1
]}

Di Credico, Barbara ^{[1
]}

Andreotti, Daniele ^{[2
]}

Mingardi, Anna ^{[2
]}

Paio, Alfredo ^{[2
]}

Donati, Daniele ^{[3
]}

Pezzati, Bernardo ^{[1
]}

Mordini, Alessandro ^{[1
]}

机构：

[1] CNR, ICCOM, Dipartimento Chim Organ U Schiff, I-50019 Sesto Fiorentino, Italy

[2] GlaxoSmithKline, Med Res Ctr, I-37135 Verona, Italy

[3] Nerviano Med Sci Srl, I-20014 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 02期

关键词：

ACTIVATING-FACTOR PAF; POTENT; INHIBITION; ANTAGONISM; BINDING;

D O I：

10.1016/j.tetasy.2009.12.025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New enantiomerically enriched 1,4,5-piperazines and 1,4,5-dihydro-2H-pyrazines have been prepared by reduction of the corresponding 2-oxo-piperazines. Selective reduction can be achieved by careful control of the reaction conditions using LiAlH4. Notably the two nitrogen atoms of the final compounds are orthogonally protected. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：191 / 194

页数：4

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