Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines

被引：37

作者：

Markovic, Zoran M. ^{[1
]}

Jovanovic, Svetlana P. ^{[1
]}

Maskovic, Pavle Z. ^{[2
]}

Mojsin, Marija M. ^{[3
]}

Stevanovic, Milena J. ^{[3
,4
,5
]}

Danko, Martin ^{[6
]}

Micusik, Matej ^{[6
]}

Jovanovic, Dragana J. ^{[1
]}

Kleinova, Angela ^{[6
]}

Spitalsky, Zdeno ^{[6
]}

Pavlovic, Vladimir B. ^{[7
]}

Markovic, Biljana M. Todorovic ^{[1
]}

机构：

[1] Univ Belgrade, Vinca Inst Nucl Sci, POB 522, Belgrade 11001, Serbia

[2] Univ Kragujevac, Fac Agron Cacak, Cara Dusana 34, Cacak 32000, Serbia

[3] Univ Belgrade, Inst Mol Genet & Genet Engn, POB 23, Belgrade 11010, Serbia

[4] Univ Belgrade, Fac Biol, Studentski Trg 16, Belgrade 11000, Serbia

[5] Serbian Acad Arts & Sci, Knez Mihailova 35, Belgrade 11000, Serbia

[6] Slovak Acad Sci, Inst Polymer, Dubravska Cesta 9, Bratislava 84541, Slovakia

[7] Univ Belgrade, Fac Agr, Dept Agr Engn, Nemanjina 6, Zemun 11080, Serbia

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2019年 / 200卷

关键词：

Graphene oxide; Graphene quantum dots; Carbon quantum dots; Reactive oxygen species; CARBON QUANTUM DOTS; ANTIBACTERIAL ACTIVITY; OXYGEN GENERATION; NANOMATERIALS; AUTOPHAGY;

D O I：

10.1016/j.jphotobiol.2019.111647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.

引用

页数：10

共 54 条

[1] New photosensitizers for photodynamic therapy [J].

Abrahamse, Heidi ;

Hamblin, Michael R. .

BIOCHEMICAL JOURNAL, 2016, 473 :347-364

[2] Photodynamic Therapy (PDT): PDT Mechanisms [J].

Allison, Ron R. ;

Moghissi, Keyvan .

CLINICAL ENDOSCOPY, 2013, 46 (01) :24-29

[3] PHOTOPHYSICAL PROPERTIES OF C60 [J].

ARBOGAST, JW ;

DARMANYAN, AP ;

FOOTE, CS ;

RUBIN, Y ;

DIEDERICH, FN ;

ALVAREZ, MM ;

ANZ, SJ ;

WHETTEN, RL .

JOURNAL OF PHYSICAL CHEMISTRY, 1991, 95 (01) :11-12

[4]

Baviskar M.R., 2012, Der Pharm. Sin, V3, P24

[5] Mitigating the Cytotoxicity of Graphene Quantum Dots and Enhancing Their Applications in Bioimaging and Drug Delivery [J].

Chandra, Anil ;

Deshpande, Sonal ;

Shinde, Dhanraj B. ;

Pillai, Vijayamohanan K. ;

Singh, Neetu .

ACS MACRO LETTERS, 2014, 3 (10) :1064-1068

[6] Graphene oxide as a chemosensitizer: Diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects [J].

Chen, Guan-Yu ;

Meng, Chia-Le ;

Lin, Kuan-Chen ;

Tuan, Hsing-Yu ;

Yang, Hong-Jie ;

Chen, Chiu-Ling ;

Li, Kuei-Chang ;

Chiang, Chi-Shiun ;

Hu, Yu-Chen .

BIOMATERIALS, 2015, 40 :12-22

[7] Tunable Photoluminescence from Graphene Oxide [J].

Chien, Chih-Tao ;

Li, Shao-Sian ;

Lai, Wei-Jung ;

Yeh, Yun-Chieh ;

Chen, Hsin-An ;

Chen, I-Shen ;

Chen, Li-Chyong ;

Chen, Kuei-Hsien ;

Nemoto, Takashi ;

Isoda, Seiji ;

Chen, Mingwei ;

Fujita, Takeshi ;

Eda, Goki ;

Yamaguchi, Hisato ;

Chhowalla, Manish ;

Chen, Chun-Wei .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (27) :6662-6666

[8] Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light [J].

Chong, Yu ;

Ge, Cuicui ;

Fang, Ge ;

Tian, Xin ;

Ma, Xiaochuan ;

Wen, Tao ;

Wamer, Wayne G. ;

Chen, Chunying ;

Chai, Zhifang ;

Yin, Jun-Jie .

ACS NANO, 2016, 10 (09) :8690-8699

[9] Carbon Dots as Antioxidants and Prooxidants [J].

Christensen, Ingeborg Lie ;

Sun, Ya-Ping ;

Juzenas, Petras .

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2011, 7 (05) :667-676

[10]

Dresselhaus M. S., 1996, SCI FULLERENES CARBO

← 1 2 3 4 5 6 →