Plasma cGMP and large artery remodeling in asymptomatic men

被引：12

作者：

Devynck, MA ^{[1
]}

Simon, A ^{[1
]}

Pernollet, MG ^{[1
]}

Chironi, G ^{[1
]}

Gariepy, J ^{[1
]}

Rendu, F ^{[1
]}

Levenson, J ^{[1
]}

机构：

[1] Univ Paris 05, Assistance Publ Hop Paris, Hop Broussais, CNRS,UNR 7131,Ctr Med Prevent Cardiovasc, F-75674 Paris, France

来源：

HYPERTENSION | 2004年 / 44卷 / 06期

关键词：

atherosclerosis; nitric oxide; endothelium; arteries; remodeling; cyclic GMP;

D O I：

10.1161/01.HYP.0000145862.33770.e9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

cGMP regulates vascular smooth muscle tone and arterial wall response to proliferative signals. We determined plasma cGMP and carotid artery intima-media thickness (IMT) and diameter in 84 asymptomatic men submitted to investigation of their cardiovascular risk profiles. Plasma cGMP was positively associated with IMT ( P < 0.01) and diameter ( P < 0.05), independently of coexisting risk factors. These associations were reinforced in the subgroup of subjects with high-sensitivity C-reactive protein level or multiple atherosclerotic plaques. A positive relationship existed between diameter and IMT ( P < 0.01) and disappeared after cGMP adjustment. This suggests a link between cGMP pathway and arterial wall geometry that is revealed by vascular injury conditions and may participate in early large artery remodeling.

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收藏

页码：919 / 923

页数：5

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