The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats

被引：57
作者：
Cavalcante, Raissa G. S. [1 ]
de Albuquerque, Thatyane M. R. [1 ]
de Luna Freire, Micaelle O. [1 ]
Ferreira, Georgianna A. H. [1 ]
Carneiro dos Santos, Lucas A. [1 ]
Magnani, Marciane [2 ]
Cruz, Josiane C. [3 ]
Braga, Valdir A. [3 ]
de Souza, Evandro L. [1 ]
de Brito Alves, Jose L. [1 ]
机构：
[1] Univ Fed Paraiba, Hlth Sci Ctr, Dept Nutr, Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Paraiba, Technol Ctr, Dept Food Engn, Joao Pessoa, Paraiba, Brazil
[3] Univ Fed Paraiba, Biotechnol Ctr, Joao Pessoa, Paraiba, Brazil
来源：
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2019年 / 29卷 / 12期
关键词：
Dyslipidemia; Hypertension; Microbiota; Probiotics; Lactobacillus fermentum; GUT MICROBIOTA; INSULIN SENSITIVITY; BLOOD-GLUCOSE; HYPERTENSION; ACIDS; DYSLIPIDEMIA; CHOLESTEROL; PRODUCTS; STRAINS; SYSTEM;
D O I：
10.1016/j.numecd.2019.08.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and aim: High-fat (HF) diet consumption has been associated with gut dysbiosis and increased risk of dyslipidemia, type 2 diabetes mellitus and hypertension. Probiotic administration has been suggested as a safe therapeutic strategy for the treatment of cardiometabolic disorders. This study was designed to assess the effects of probiotic Lactobacillus (L.) fermentum 296, a fruit-derived bacteria strain, against cardiometabolic disorders induced by HF diet. Methods and results: Male Wistar rats were divided into control diet (CTL); HF diet; and HF diet treated with Lactobacillus fermentum 296 (HF Lf 296). The L. fermentum 296 strain at 1 x 10(9) colony forming units (CFU)/ml were daily administered by oral gavage for 4 weeks. The results showed that rats fed with HF diet displayed insulin resistance, reduced Lactobacillus spp. counts in feces, serum lipids, and oxidative profile. Rats fed on HF diet also demonstrated augmented blood pressure associated with sympathetic hyperactivity and impaired baroreflex control. The administration of L. fermentum 296 for 4 weeks recovered fecal Lactobacillus sp. counts and alleviated hyperlipidemia, sympathetic hyperactivity, and reduced systolic blood pressure in HF rats without affecting baroreflex sensibility. Conclusion: Our results suggest the ability of L. fermentum 296 improve biochemical and cardiovascular parameters altered in cardiometabolic disorders. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1408 / 1417
页数：10
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共 50 条
[1]   Qualification of tropical fruit-derived Lactobacillus plantarum strains as potential probiotics acting on blood glucose and total cholesterol levels in codetet Wistar rats [J].
Almeida da Costa, Whyara Karoline ;
Brandao, Larissa Ramalho ;
Martino, Maria Elena ;
Garcia, Estefania Fernandes ;
Alves, Adriano Francisco ;
de Souza, Evandro Leite ;
Aquino, Jailane de Souza ;
Saarela, Maria ;
Leulier, Francois ;
Vidal, Hubert ;
Magnani, Marciane .
FOOD RESEARCH INTERNATIONAL, 2019, 124 :109-117
[2]  
[Anonymous], 2018, PROB ANTIMICROB PROT
[3]  
[Anonymous], 2018, BIOFACTORS
[4]   Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice [J].
Bagarolli, Renata A. ;
Tobar, Natalia ;
Oliveira, Alexandre G. ;
Araujo, Tiago G. ;
Carvalho, Bruno M. ;
Rocha, Guilherme Z. ;
Vecina, Juliana F. ;
Calisto, Kelly ;
Guadagnini, Dioze ;
Prada, Patricia O. ;
Santos, Andrey ;
Saad, Sara T. O. ;
Saad, Mario J. A. .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2017, 50 :16-25
[5]   Serum Lipids During 20 Years in the Tehran Lipid and Glucose Study: Prevalence, Trends and Impact on Non-Communicable Diseases [J].
Baghbani-Oskouei, Aidin ;
Tohidi, Maryam ;
Asgari, Samaneh ;
Ramezankhani, Azra ;
Azizi, Fereidoun ;
Hadaegh, Farzad .
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2018, 16 (04)
[6]   Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice [J].
Balakumar, Mahalingam ;
Prabhu, Durai ;
Sathishkumar, Chandrakumar ;
Prabu, Paramasivam ;
Rokana, Namita ;
Kumar, Ramesh ;
Raghavan, Srividhya ;
Soundarajan, Avinash ;
Grover, Sunita ;
Batish, Virender Kumar ;
Mohan, Viswanathan ;
Balasubramanyam, Muthuswamy .
EUROPEAN JOURNAL OF NUTRITION, 2018, 57 (01) :279-295
[7]  
Batista KS, 2018, BRIT J NUTR, V119, P30, DOI [10.1017/S0007114517003282, 10.1017/s0007114517003282]
[8]   Strain-specific probiotic properties of lactic acid bacteria and their interference with human intestinal pathogens invasion [J].
Campana, Raffaella ;
van Hemert, Saskia ;
Baffone, Wally .
GUT PATHOGENS, 2017, 9
[9]   Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats [J].
Carvalho-Galvao, Alynne ;
Ogunlade, Blessing ;
Xu, Jiaxi ;
Silva-Alves, Cristiane R. A. ;
Mendes-Junior, Leonidas G. ;
Guimaraes, Drielle D. ;
Cruz, Josiane C. ;
Queiroz, Thyago M. ;
Balarini, Camille M. ;
Braga, Valdir A. ;
Filipeanu, Catalin M. ;
Lazartigues, Eric ;
de Franca-Silva, Maria do Socorro .
CLINICAL SCIENCE, 2018, 132 (14) :1513-1527
[10]   Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease? [J].
Cavalcanti Neto, Marinaldo Pacifico ;
Aquino, Jailane de Souza ;
Romao da Silva, Larissa de Fatima ;
Silva, Ruanniere de Oliveira ;
de Lima Guimaraes, Keyth Sulamitta ;
de Oliveira, Yohanna ;
de Souza, Evandro Leite ;
Magnani, Marciane ;
Vidal, Hubert ;
de Brito Alves, Jose Luiz .
PHARMACOLOGICAL RESEARCH, 2018, 130 :152-163
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