Depression in Sub-Saharan Africa

被引：41

作者：

Gbadamosi, Ismail Temitayo ^{[1
,10
]}

Henneh, Isaac Tabiri ^{[2
]}

Aluko, Oritoke Modupe ^{[3
]}

Yawson, Emmanuel Olusola ^{[4
]}

Fokoua, Aliance Romain ^{[5
]}

Koomson, Awo ^{[6
]}

Torbi, Joseph ^{[6
]}

Olorunnado, Samson Ehindero ^{[7
]}

Lewu, Folashade Susan ^{[1
]}

Yusha'u, Yusuf ^{[8
]}

Keji-Taofik, Salmat Temilola ^{[1
]}

Biney, Robert Peter ^{[2
]}

Tagoe, Thomas Amatey ^{[9
]}

机构：

[1] Univ Ilorin, Dept Anat, Ilorin, Nigeria

[2] Univ Cape Coast, Sch Pharm & Pharmaceut Sci, Dept Pharmacotherapeut & Pharm Practice, Cape Coast, Ghana

[3] Fed Univ Technol Akure, Sch Basic Med Sci, Dept Physiol, Akure, Nigeria

[4] Redeemers Univ, Dept Anat, Ede, Nigeria

[5] Univ Dschang, Dept Anim Biol, Dschang, Cameroon

[6] Toxicol Univ Ghana, Dept Pharmacol, Accra, Ghana

[7] Kogi State Univ, Dept Anat, Anyigba, Nigeria

[8] Ahmadu Bello Univ, Dept Human Physiol, Zaria, Nigeria

[9] Univ Ghana, Physiol Dept, Accra, Ghana

[10] BRAINCITY Nencki EMBL Ctr Excellence Neural Plasti, Lab Translat Res Neuropsychiat Disorders, Warsaw, Poland

来源：

IBRO NEUROSCIENCE REPORTS | 2022年 / 12卷

关键词：

Poland; Major depressive disorder; Antidepressants; Sub-Saharan Africa; Medicinal plants; SELF-REPORTING QUESTIONNAIRE; COMMON MENTAL-DISORDERS; FORCED SWIMMING TEST; HOPKINS SYMPTOM CHECKLIST-25; ANTIDEPRESSANT-LIKE ACTIVITY; DIRECT-CURRENT STIMULATION; CONCENTRIC SQUARE FIELD; POSITIVE PREGNANT-WOMEN; NEUROTROPHIC FACTOR; PSYCHIATRIC MORBIDITY;

D O I：

10.1016/j.ibneur.2022.03.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mood disorders can be considered among the most common and debilitating mental disorders. Major depression, as an example of mood disorders, is known to severely reduce the quality of life as well as psychosocial functioning of those affected. Its impact on the burden of disease worldwide has been enormous, with the World Health Organisation projecting depression to be the leading cause of mental illness by 2030. Despite several studies on the subject, little has been done to contextualise the condition in Africa, coupled with the fact that there is still much to be understood on the subject. This review attempts to shed more light on the prevalence of depression in Sub-Saharan Africa (SSA), its pathophysiology, risk factors, diagnosis and the experimental models available to study depression within the sub-region. It also evaluates the contribution of the sub-region to the global research output of depression as well as bottlenecks associated with full exploitation of the sub region's resources to manage the disorder.

引用

页码：309 / 322

页数：14

共 261 条

[81] Intrahippocampal Effects of Nickel Injection on the Affective and Cognitive Response in Wistar Rat: Potential Role of Oxidative Stress [J].