Higher carotid-radial pulse wave velocity is associated with non-melancholic depressive symptoms in men - findings from Helsinki Birth Cohort Study

被引:8
作者
Eriksson, Mia D. [1 ]
Eriksson, Johan G. [2 ,3 ,4 ,5 ,6 ,7 ]
Kautiainen, Hannu [2 ,8 ]
Salonen, Minna K. [2 ,9 ]
Mikkola, Tuija M. [2 ,10 ]
Kajantie, Eero [11 ,12 ,13 ]
Wasenius, Niko [2 ,3 ,4 ]
von Bonsdorff, Mikaela [2 ,14 ,15 ]
Korhonen, Paivi [16 ,17 ]
Laine, Merja K. [2 ,3 ,4 ]
机构
[1] Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland
[2] Folkhalsan Res Ctr, Helsinki, Finland
[3] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland
[4] Helsinki Univ Hosp, Helsinki, Finland
[5] Natl Univ Singapore, Dept Obstet & Gynecol, Singapore, Singapore
[6] Natl Univ Singapore, Human Potential Translat Res Programme Yong Loo L, Singapore, Singapore
[7] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore
[8] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
[9] Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Dept Publ Hlth Solut, Helsinki, Finland
[10] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland
[11] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland
[12] Univ Oulu, Oulu, Finland
[13] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
[14] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland
[15] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland
[16] Turku Univ Hosp, Dept Gen Practice, Turku, Finland
[17] Univ Turku, Turku, Finland
基金
欧盟地平线“2020”; 芬兰科学院;
关键词
Cohort study; comorbidity; depression; depressive disorder; pulse wave velocity; SMALL-VESSEL DISEASE; MIDDLE-AGED MEN; ARTERIAL STIFFNESS; ENDOTHELIAL DYSFUNCTION; VASCULAR DEPRESSION; METABOLIC SYNDROME; AORTIC STIFFNESS; BLOOD-PRESSURE; POPULATION; RISK;
D O I
10.1080/07853890.2021.1904277
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Depression and cardiovascular disease (CVD) are major causes of global disease burden that are interrelated through mostly unknown mechanisms. We studied the relationship of melancholic and non-melancholic depressive symptoms with arterial stiffness, an important underlying mechanism of CVD. Methods The Helsinki Birth Cohort Study recruited 683 previously extensively phenotyped subjects for this sub-study. Cross-sectional data along with responses regarding depressive symptoms were obtained for each participant. For evaluation of depressive symptoms, the Beck Depression Inventory (BDI)and subscales were used to measure melancholic and non-melancholic depressive symptoms. Arterial stiffness was assessed as pulse wave velocity (PWV) that was measured between the carotid and radial artery, and carotid and femoral artery. Results Of the participants, 532 scored <10 on the BDI and were classified as not having depressive symptoms. Of the 151 participants that scored >= 10 on the BDI, 122 were classified as having non-melancholic depressive symptoms and 29 as having melancholic depressive symptoms. Men had higher carotid-radial PWV (crPWV) values than women (p < .001). A positive relationship between BDI scores and crPWV (p < .001) was found in men. We also found higher crPWV in men with non-melancholic depressive symptoms compared to all others. No such differences were found in women. Discussion Arterial stiffness has a relationship with depressive symptoms and subtypes of depressive symptoms, at least in men. There is a significant relationship between higher PWV and non-melancholic depressive symptoms in men. Due to the intricate nature of the disease causality or directionality is impossible to infer solely based on this study. Further studies into the subtypes of depressive symptoms may be of benefit to understanding depression. KEY MESSAGES It is known that arterial stiffness contributes to cardiovascular disease, and is associated with depression. Higher Beck Depression Inventory scores are associated with higher carotid-radial pulse wave velocity in men. Non-melancholic depressive symptoms are associated with higher carotid-radial pulse wave velocity in men.
引用
收藏
页码:531 / 540
页数:10
相关论文
共 65 条
[1]   2011 Compendium of Physical Activities: A Second Update of Codes and MET Values [J].
Ainsworth, Barbara E. ;
Haskell, William L. ;
Herrmann, Stephen D. ;
Meckes, Nathanael ;
Bassett, David R., Jr. ;
Tudor-Locke, Catrine ;
Greer, Jennifer L. ;
Vezina, Jesse ;
Whitt-Glover, Melicia C. ;
Leon, Arthur S. .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2011, 43 (08) :1575-1581
[2]   Treatment resistant depression: A multi-scale, systems biology approach [J].
Akil, Huda ;
Gordon, Joshua ;
Hen, Rene ;
Javitch, Jonathan ;
Mayberg, Helen ;
McEwen, Bruce ;
Meaney, Michael J. ;
Nestler, Eric J. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2018, 84 :272-288
[3]  
Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
[4]   Trajectories of growth among children who have coronary events as adults [J].
Barker, DJP ;
Osmond, C ;
Forsén, TJ ;
Kajantie, E ;
Eriksson, JG .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1802-1809
[5]   AN INVENTORY FOR MEASURING DEPRESSION [J].
BECK, AT ;
ERBAUGH, J ;
WARD, CH ;
MOCK, J ;
MENDELSOHN, M .
ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&
[6]   PSYCHOMETRIC PROPERTIES OF THE BECK DEPRESSION INVENTORY - 25 YEARS OF EVALUATION [J].
BECK, AT ;
STEER, RA ;
GARBIN, MG .
CLINICAL PSYCHOLOGY REVIEW, 1988, 8 (01) :77-100
[7]   Memory and executive function in aging and AD: Multiple factors that cause decline and reserve factors that compensate [J].
Buckner, RL .
NEURON, 2004, 44 (01) :195-208
[8]   A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].
CHARLSON, ME ;
POMPEI, P ;
ALES, KL ;
MACKENZIE, CR .
JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383
[9]   Arterial stiffness, vascular disease, and risk of cardiovascular events [J].
Cohn, JN .
CIRCULATION, 2006, 113 (05) :601-603
[10]   Pulse Wave Velocity Ratio The New "Gold Standard" for Measuring Arterial Stiffness [J].
Covic, Adrian ;
Siriopol, Dimitrie .
HYPERTENSION, 2015, 65 (02) :289-290