Preferentially Expressed Antigen in Melanoma (PRAME) and Human Malignant Melanoma: A Retrospective Study

被引：15

作者：

Cazzato, Gerardo ^{[1
]}

Mangialardi, Katia ^{[1
]}

Falcicchio, Giovanni ^{[2
]}

Colagrande, Anna ^{[1
]}

Ingravallo, Giuseppe ^{[1
]}

Arezzo, Francesca ^{[2
]}

Giliberti, Giovanna ^{[1
]}

Trilli, Irma ^{[3
]}

Loizzi, Vera ^{[2
]}

Lettini, Teresa ^{[1
]}

Scarcella, Sara ^{[1
]}

Annese, Tiziana ^{[4
,5
]}

Parente, Paola ^{[6
]}

Lupo, Carmelo ^{[7
]}

Casatta, Nadia ^{[7
]}

Maiorano, Eugenio ^{[1
]}

Cormio, Gennaro ^{[2
]}

Resta, Leonardo ^{[1
]}

Ribatti, Domenico ^{[5
]}

机构：

[1] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat DETO, Sect Pathol, I-70124 Bari, Italy

[2] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol DIMO, Sect Gynecol & Obstet, I-70124 Bari, Italy

[3] Univ G dAnnunzio, Dept Innovat Technol Med & Dent, Odontostomatol Clin, I-66100 Chieti, Italy

[4] LUM Univ, Dept Med & Surg, I-70124 Casamassima, Italy

[5] Univ Bari, Dept Basic Med Sci Neurosci & Sensory Organs, Sect Human Anat & Histol, Med Sch, I-70124 Bari, Italy

[6] Fdn IRCCS Casa Sollievo Sofferenza, Pathol Unit, I-71013 San Giovanni Rotondo, Italy

[7] Diapath SpA, Innovat Dept, Via Savoldini 71, I-24057 Martinengo, Italy

来源：

GENES | 2022年 / 13卷 / 03期

关键词：

PRAME; malignant melanoma; skin; differential diagnosis; histopathology; DIFFERENTIAL-DIAGNOSIS; DESMOPLASTIC MELANOMA; CANCER; TUMOR; IMMUNOHISTOCHEMISTRY; METASTASIS; TARGET; HMB-45;

D O I：

10.3390/genes13030545

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Preferentially expressed antigen in melanoma (PRAME) is a cancer testis antigen (CTA) identified in 1997 through analysis of the specificity of tumor-reactive T-cell clones derived from a patient with metastatic cutaneous melanoma. Although at first it seemed even more specific, various studies have shown that PRAME can also be expressed in the context of atypical lesions that do not correspond solely to the definition of malignant melanoma. Methods: A systematic review of English articles was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: 126 records were identified in the literature search, of which 9 were duplicates. After screening for eligibility and inclusion criteria, 53 publications were included. Conclusions: The advent of a new marker such as PRAME is surely a step forward not only in the diagnostic approach, but also in the immunotherapeutic approach to MM. However, various studies have shown that PRAME can also be expressed in the context of atypical lesions apart from MM and, for this reason, the diagnostic sensitivity and specificity (hence accuracy) are clearly lower. Further studies with larger case series will be necessary to understand better what possibilities are offered in terms of diagnostic reliability by PRAME.

引用

页数：9

共 69 条

[1] PRAME immunohistochemistry as an adjunct in the diagnosis of paucicellular lentigo maligna in a young man [J].