Reliability of HR-pQCT Derived Cortical Bone Structural Parameters When Using Uncorrected Instead of Corrected Automatically Generated Endocortical Contours in a Cross-Sectional Study: The Maastricht Study

被引：12

作者：

de Waard, Ellis A. C. ^{[1
,2
]}

Sarodnik, Cindy ^{[1
,2
]}

Pennings, Alexander ^{[1
]}

de Jong, Joost J. A. ^{[1
,2
]}

Savelberg, Hans H. C. M. ^{[2
,3
]}

van Geel, Tineke A. ^{[2
,4
,5
]}

van der Kallen, Carla J. ^{[6
,7
]}

Stehouwer, Coen D. A. ^{[6
,7
]}

Schram, Miranda T. ^{[6
,7
,8
]}

Schaper, Nicolaas ^{[4
,6
,7
]}

Dagnelie, Pieter C. ^{[6
,7
]}

Geusens, Piet P. M. M. ^{[4
,9
,10
]}

Koster, Annemarie ^{[4
,11
]}

van Rietbergen, Bert ^{[12
]}

van den Bergh, Joop P. W. ^{[2
,9
,10
,13
]}

机构：

[1] Maastricht Univ, Dept Internal Med, Subdiv Rheumatol, POB 616, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands

[3] Maastricht Univ, Dept Human Movement Sci, Maastricht, Netherlands

[4] Maastricht Univ, CAPHRI, Maastricht, Netherlands

[5] Maastricht Univ, Dept Family Med, Maastricht, Netherlands

[6] Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands

[7] Maastricht Univ, CARIM Sch Cardiovasc Dis, Maastricht, Netherlands

[8] Maastricht Univ, Heart & Vasc Ctr, Med Ctr, Maastricht, Netherlands

[9] Maastricht Univ, Dept Internal Med, Subdiv Rheumatol, Med Ctr, Maastricht, Netherlands

[10] Univ Hasselt, Biomed Res Inst, Hasselt, Belgium

[11] Maastricht Univ, Dept Social Med, Maastricht, Netherlands

[12] Eindhoven Univ Technol, Fac Biomed Engn, Eindhoven, Netherlands

[13] VieCuri Med Ctr, Dept Internal Med, Subdiv Endocrinol, Venlo, Netherlands

来源：

CALCIFIED TISSUE INTERNATIONAL | 2018年 / 103卷 / 03期

关键词：

High resolution peripheral quantitative computed tomography; Bone microarchitecture; Cortical bone analysis; Endocortical contour; DISTAL RADIUS; TRABECULAR COMPARTMENTS; POSTMENOPAUSAL WOMEN; COMPUTED-TOMOGRAPHY; PRECISION; POROSITY; MICROARCHITECTURE; QUALITY; TIBIA; REPRODUCIBILITY;

D O I：

10.1007/s00223-018-0416-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most HR-pQCT studies examining cortical bone use an automatically generated endocortical contour (AUTO), which is manually corrected if it visually deviates from the apparent endocortical margin (semi-automatic method, S-AUTO). This technique may be prone to operator-related variability and is time consuming. We examined whether the AUTO instead of the S-AUTO method can be used for cortical bone analysis. Fifty scans of the distal radius and tibia from participants of The Maastricht Study were evaluated with AUTO, and subsequently with S-AUTO by three independent operators. AUTO cortical bone parameters were compared to the average parameters obtained by the three operators (S-AUTOmean). All differences in mean cortical bone parameters between AUTO and S-AUTOmean were < 5%, except for lower AUTO cortical porosity of the radius (- 16%) and tibia (- 6%), and cortical pore volume (Ct.Po.V) of the radius (- 7%). The ICC of S-AUTOmean and AUTO was > 0.90 for all parameters, except for cortical pore diameter of the radius (0.79) and tibia (0.74) and Ct.Po.V of the tibia (0.89), without systematic errors on the Bland-Altman plots. The precision errors (RMS-CV%) of the radius parameters between S-AUTOmean and AUTO were comparable to those between the individual operators, whereas the tibia RMS-CV% between S-AUTOmean and AUTO were higher than those of the individual operators. Comparison of the three operators revealed clear inter-operator variability. This study suggests that the AUTO method can be used for cortical bone analysis in a cross-sectional study, but that the absolute values-particularly of the porosity-related parameters-will be lower.

引用

页码：252 / 265

页数：14

共 26 条

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