Alteration of Nociceptive Integration in the Spinal Cord of a Rat Model of Parkinson's Disease

被引：31

作者：

Charles, Keri-Ann ^{[1
,2
]}

Naudet, Frederic ^{[1
,2
]}

Bouali-Benazzouz, Rabia ^{[3
]}

Landry, Marc ^{[3
]}

De Deurwaerdere, Philippe ^{[1
,2
]}

Fossat, Pascal ^{[3
]}

Benazzouz, Abdelhamid ^{[1
,2
]}

机构：

[1] Univ Bordeaux, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France

[2] CNRS, Inst Malad Neurodegenerat, UMR 5293, Bordeaux, France

[3] CNRS, Intitut Interdisciplinaire Neurosci, UMR5297, Bordeaux, France

来源：

MOVEMENT DISORDERS | 2018年 / 33卷 / 06期

关键词：

Parkinson's disease; pain; 6-hydroxydopamine; dorsal horn; rat; DEEP BRAIN-STIMULATION; NONMOTOR MANIFESTATIONS; PAIN; NEURONS; SENSATION; RESPONSES;

D O I：

10.1002/mds.27377

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Pain is a major non motor symptom that contributes to impaired quality of life in PD. However, its mechanism is unknown. Objectives and Methods: We sought to identify the pain phenotypes and parallel changes in spinal integration of peripheral stimuli in a rat model of PD induced by lesions of SN dopamine neurons, using behavioral plantar and von Frey tests as well as electrophysiology of the dorsal horn. Results: We show that dopamine depletion by 6-OHDA induced hypersensitivity to mechanical and thermal stimuli. These abnormal behaviors were paralleled by increased neuronal responses and hyperexcitability of wide dynamic range neurons of lamina V of the dorsal horn of the spinal cord in response to electrical stimulation of the sciatic nerve in the 6-OHDA model as compared to sham rats. Conclusions: These results provide evidence for alteration of nociceptive integration in the spinal dorsal horn neurons in 6-OHDA rats that can reflect changes in pain behavior. (C) 2018 International Parkinson and Movement Disorder Society

引用

页码：1010 / 1015

页数：6

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