The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma

被引：21

作者：

Barraclough, Allison ^{[1
,2
]}

Bishton, Mark ^{[3
]}

Cheah, Chan Y. ^{[4
,5
]}

Villa, Diego ^{[6
,7
]}

Hawkes, Eliza A. ^{[8
,9
]}

机构：

[1] Austin Hlth, Dept Haematol, Melbourne, Vic, Australia

[2] Fiona Stanley Hosp, Dept Haematol, Perth, WA, Australia

[3] Nottingham City Hosp, Dept Haematol, Nottingham, England

[4] Sir Charles Gairdner Hosp, Dept Haematol, Perth, WA, Australia

[5] Univ Western Australia, Med Sch, Perth, WA, Australia

[6] British Columbia Canc, Ctr Lymphoid Canc, Vancouver, BC, Canada

[7] Univ British Columbia, Vancouver, BC, Canada

[8] Austin Hlth, Olivia Newton John Canc Res & Wellness Ctr, Dept Med Oncol & Haematol, Melbourne, Vic, Australia

[9] Eastern Hlth, Dept Med Oncol & Haematol, Melbourne, Vic, Australia

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 195卷 / 01期

关键词：

lymphoma; lymphoproliferative disease; non‐ Hodgkin lymphoma; lymphoid malignancies; B-CELL LYMPHOMA; EUROPEAN-AMERICAN CLASSIFICATION; HIGH-DOSE THERAPY; PROGNOSTIC VALUE; AUTOLOGOUS TRANSPLANTATION; MAINTENANCE RITUXIMAB; HISTOLOGIC GRADE; EXPRESSION; BCL6; ANTHRACYCLINE;

D O I：

10.1111/bjh.17404

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Grade 3B follicular lymphoma (G3B FL) is rare, accounting for only 5-10% of FLs. Not only has it been routinely excluded from clinical trials, but data published on diagnosis, outcomes, choice of therapies and role of imaging are conflicting. With the advent of increasingly diverse treatment options for low-grade (G1-3A) FL, and the molecular subcategorisation of high-grade B-cell lymphomas, characterisation and treatment of G3B FL is ever more important as extrapolation of data becomes more difficult. New data have emerged exploring unique genetic characteristics, specific features on positron emission tomography imaging, choice of therapy, and outcomes of G3B FL in the current era. The present review will summarise and appraise these new data, and offer recommendations based on current evidence.

引用

页码：15 / 24

页数：10

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