Grifola Frondosa Polysaccharide: A Review of Antitumor and Other Biological Activity Studies in China

被引：2

作者：

He, Yanli ^{[1
,2
]}

Li, Xiulian ^{[1
,2
]}

Hao, Cui ^{[2
]}

Zeng, Pengjiao ^{[2
]}

Zhang, Meng ^{[2
]}

Liu, Yong ^{[2
]}

Chang, Yajing ^{[1
,2
]}

Zhang, Lijuan ^{[2
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Shandong, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Inst Cerebrovasc Dis, Qingdao 266003, Shandong, Peoples R China

来源：

DISCOVERY MEDICINE | 2018年 / 25卷 / 138期

关键词：

D-FRACTION; MAITAKE MUSHROOM; MICE; COMBINATION; CELLS; RATS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Grifola frondosa, a species of Basidiomycotina, is an edible medicinal mushroom with a large fruiting body characterized by overlapping caps. The beta-glucan is the major biologically active component in G. frondosa polysaccharide (GFP) or D-fraction, which has been studied extensively for nearly 30 years. GFP was approved as an adjunctive therapeutic drug in China for treating cancers in 2010. In this article, based on the search results of Chinese VIP, CNKI, and Wanfang databases, 105 independent animal studies were summarized. The chemical structure, the antitumor, immunomodulatory, anti-diabetic, anti-hyperlipidemia, and antiviral activities and molecular mechanisms of GFP are reviewed and discussed.

引用

页码：159 / 176

页数：18