Vacancy-Engineered Nanoceria: Enzyme Mimetic Hotspots for the Degradation of Nerve Agents

被引：187

作者：

Vernekar, Amit A. ^{[1
]}

Das, Tandrila ^{[1
]}

Mugesh, Govindasamy ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 04期

关键词：

enzyme models; heterogeneous catalysis; nanozymes; nerve agents; phosphotriesterase; BINUCLEAR METAL CENTER; GRAPHENE OXIDE; PEROXIDASE; HYDROLYSIS; NANOPARTICLES; DESTRUCTION; NANOSHEETS; REDUCTION; NANOZYMES; EXPOSURE;

D O I：

10.1002/anie.201510355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Organophosphorus-based nerve agents, such as paraoxon, parathion, and malathion, inhibit acetylcholinesterase, which results in paralysis, respiratory failure, and death. Bacteria are known to use the enzyme phosphotriesterase (PTE) to break down these compounds. In this work, we designed vacancy-engineered nanoceria (VE CeO2 NPs) as PTE mimetic hotspots for the rapid degradation of nerve agents. We observed that the hydrolytic effect of the nano-material is due to the synergistic activity between both Ce3+ and Ce4+ ions located in the active site-like hotspots. Furthermore, the catalysis by nanoceria overcomes the product inhibition generally observed for PTE and small molecule-based PTE mimetics.

引用

页码：1412 / 1416

页数：5

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