Vitamin C in Stem Cell Reprogramming and Cancer

被引：137
作者：
Cimmino, Luisa [1 ,2 ]
Neel, Benjamin G. [2 ]
Aifantis, Iannis [1 ,2 ]
机构：
[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
[2] NYU, Sch Med, Laura & Isaac Perlmutter Canc Ctr, New York, NY 10016 USA
来源：
TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 09期
关键词：
I CLINICAL-TRIAL; ASCORBIC-ACID; DNA DEMETHYLATION; SELF-RENEWAL; TET2; FUNCTION; FTO GENE; 5-METHYLCYTOSINE; METHYLATION; FAMILY; HYDROXYLATION;
D O I：
10.1016/j.tcb.2018.04.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Vitamin C is an essential dietary requirement for humans. In addition to its known role as an antioxidant, vitamin C is a cofactor for Fe2+- and alpha-ketoglutarate-dependent dioxygenases (Fe2+/alpha-KGDDs) which comprise a large number of diverse enzymes, including collagen prolyl hydroxylases and epigenetic regulators of histone and DNA methylation. Vitamin C can modulate embryonic stem cell (ESC) function, enhance reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs), and hinder the aberrant self-renewal of hematopoietic stem cells (HSCs) through its ability to enhance the activity of either Jumonji C (JmjC) domain-containing histone demethylases or ten-eleven translocation (TET) DNA hydroxylases. Given that epigenetic dysregulation is a known driver of malignancy, vitamin C may play a novel role as an epigenetic anticancer agent.
引用
收藏
页码：698 / 708
页数：11
相关论文
共 84 条
  • [41] Hypoxia-inducible factors, stem cells, and cancer
    Keith, Brian
    Simon, M. Celeste
    [J]. CELL, 2007, 129 (03) : 465 - 472
  • [42] Kim Hyemin, 2012, Immune Netw, V12, P18, DOI 10.4110/in.2012.12.1.18
  • [43] JmjC-domain-containing proteins and histone demethylation
    Klose, Robert J.
    Kallin, Eric M.
    Zhang, Yi
    [J]. NATURE REVIEWS GENETICS, 2006, 7 (09) : 715 - 727
  • [44] Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
    Ko, Myunggon
    Bandukwala, Hozefa S.
    An, Jungeun
    Lamperti, Edward D.
    Thompson, Elizabeth C.
    Hastie, Ryan
    Tsangaratou, Angeliki
    Rajewsky, Klaus
    Koralov, Sergei B.
    Rao, Anjana
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (35) : 14566 - 14571
  • [45] Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    Ko, Myunggon
    Huang, Yun
    Jankowska, Anna M.
    Pape, Utz J.
    Tahiliani, Mamta
    Bandukwala, Hozefa S.
    An, Jungeun
    Lamperti, Edward D.
    Koh, Kian Peng
    Ganetzky, Rebecca
    Liu, X. Shirley
    Aravind, L.
    Agarwal, Suneet
    Maciejewski, Jaroslaw P.
    Rao, Anjana
    [J]. NATURE, 2010, 468 (7325) : 839 - 843
  • [46] Ascorbate as a co-factor for Fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression
    Kuiper, Caroline
    Vissers, Margreet C. M.
    [J]. FRONTIERS IN ONCOLOGY, 2014, 4
  • [47] FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    Lando, D
    Peet, DJ
    Gorman, JJ
    Whelan, DA
    Whitelaw, ML
    Bruick, RK
    [J]. GENES & DEVELOPMENT, 2002, 16 (12) : 1466 - 1471
  • [48] The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!
    Lane, Darius J. R.
    Richardson, Des R.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2014, 75 : 69 - 83
  • [49] Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
    Li, Zhe
    Cai, Xiaoqiang
    Cai, Chen-Leng
    Wang, Jiapeng
    Zhang, Wenyong
    Petersen, Bruce E.
    Yang, Feng-Chun
    Xu, Mingjiang
    [J]. BLOOD, 2011, 118 (17) : 4509 - 4518
  • [50] Regulation of Vitamin C Homeostasis during Deficiency
    Lindblad, Maiken
    Tveden-Nyborg, Pernille
    Lykkesfeldt, Jens
    [J]. NUTRIENTS, 2013, 5 (08) : 2860 - 2879
123456789