Vitamin C in Stem Cell Reprogramming and Cancer

被引：142
作者：
Cimmino, Luisa [1 ,2 ]
Neel, Benjamin G. [2 ]
Aifantis, Iannis [1 ,2 ]
机构：
[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
[2] NYU, Sch Med, Laura & Isaac Perlmutter Canc Ctr, New York, NY 10016 USA
来源：
TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 09期
关键词：
I CLINICAL-TRIAL; ASCORBIC-ACID; DNA DEMETHYLATION; SELF-RENEWAL; TET2; FUNCTION; FTO GENE; 5-METHYLCYTOSINE; METHYLATION; FAMILY; HYDROXYLATION;
D O I：
10.1016/j.tcb.2018.04.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Vitamin C is an essential dietary requirement for humans. In addition to its known role as an antioxidant, vitamin C is a cofactor for Fe2+- and alpha-ketoglutarate-dependent dioxygenases (Fe2+/alpha-KGDDs) which comprise a large number of diverse enzymes, including collagen prolyl hydroxylases and epigenetic regulators of histone and DNA methylation. Vitamin C can modulate embryonic stem cell (ESC) function, enhance reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs), and hinder the aberrant self-renewal of hematopoietic stem cells (HSCs) through its ability to enhance the activity of either Jumonji C (JmjC) domain-containing histone demethylases or ten-eleven translocation (TET) DNA hydroxylases. Given that epigenetic dysregulation is a known driver of malignancy, vitamin C may play a novel role as an epigenetic anticancer agent.
引用
收藏
页码：698 / 708
页数：11
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