Vitamin C in Stem Cell Reprogramming and Cancer

被引：142

作者：

Cimmino, Luisa ^{[1
,2
]}

Neel, Benjamin G. ^{[2
]}

Aifantis, Iannis ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[2] NYU, Sch Med, Laura & Isaac Perlmutter Canc Ctr, New York, NY 10016 USA

来源：

TRENDS IN CELL BIOLOGY | 2018年 / 28卷 / 09期

关键词：

I CLINICAL-TRIAL; ASCORBIC-ACID; DNA DEMETHYLATION; SELF-RENEWAL; TET2; FUNCTION; FTO GENE; 5-METHYLCYTOSINE; METHYLATION; FAMILY; HYDROXYLATION;

D O I：

10.1016/j.tcb.2018.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vitamin C is an essential dietary requirement for humans. In addition to its known role as an antioxidant, vitamin C is a cofactor for Fe2+- and alpha-ketoglutarate-dependent dioxygenases (Fe2+/alpha-KGDDs) which comprise a large number of diverse enzymes, including collagen prolyl hydroxylases and epigenetic regulators of histone and DNA methylation. Vitamin C can modulate embryonic stem cell (ESC) function, enhance reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs), and hinder the aberrant self-renewal of hematopoietic stem cells (HSCs) through its ability to enhance the activity of either Jumonji C (JmjC) domain-containing histone demethylases or ten-eleven translocation (TET) DNA hydroxylases. Given that epigenetic dysregulation is a known driver of malignancy, vitamin C may play a novel role as an epigenetic anticancer agent.

引用

页码：698 / 708

页数：11

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