Double Arbuzov Reaction. Synthesis of Bis(ω-cyanoalkyl)phosphinic Acids

被引：0
|
作者：
Ragulin, V. V. [1 ]
机构：
[1] Russian Acad Sci, Inst Physiol Act Subst, Severnyi Proezd 1, Chernogolovka 142432, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
Double Arbuzov reaction; ammonium hypophosphite; bis(trimethylsilyl)hypophosphite; omega-haloalkylnitriles; bis(omega-cyanoalkyl)phosphinic acids;
D O I：
10.1134/S1070363219080292
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general method for the synthesis of symmetric bis(omega-cyanoalkyl)phosphinic acids from ammonium hypophosphite was proposed. The reaction of bis(trimethylsilyl)hypophosphite generated in situ with the omega-bromoalkylnitrile molecule according to the Arbuzov reaction and the subsequent silylation of the hydrophosphoryl intermediate leads to the formation of bis(trimethylsilyl)phosphonite. The latter reacts with the second omega-haloalkylnitrile molecule by the Arbuzov reaction with the formation of the second phosphorus-carbon bond.
引用
收藏
页码：1728 / 1730
页数：3
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