Double Arbuzov Reaction. Synthesis of Bis(ω-cyanoalkyl)phosphinic Acids

被引：0

作者：

Ragulin, V. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Physiol Act Subst, Severnyi Proezd 1, Chernogolovka 142432, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

Double Arbuzov reaction; ammonium hypophosphite; bis(trimethylsilyl)hypophosphite; omega-haloalkylnitriles; bis(omega-cyanoalkyl)phosphinic acids;

D O I：

10.1134/S1070363219080292

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general method for the synthesis of symmetric bis(omega-cyanoalkyl)phosphinic acids from ammonium hypophosphite was proposed. The reaction of bis(trimethylsilyl)hypophosphite generated in situ with the omega-bromoalkylnitrile molecule according to the Arbuzov reaction and the subsequent silylation of the hydrophosphoryl intermediate leads to the formation of bis(trimethylsilyl)phosphonite. The latter reacts with the second omega-haloalkylnitrile molecule by the Arbuzov reaction with the formation of the second phosphorus-carbon bond.

引用

页码：1728 / 1730

页数：3

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