Amebic meningoencephalitis caused by Balamuthia mandrillaris:: Case report and review

被引:42
|
作者
Denney, CF
Iragui, VJ
Uber-Zak, LD
Karpinski, NC
Ziegler, EJ
Visvesvara, GS
Reed, SL
机构
[1] Univ Calif San Diego, Med Ctr, Dept Med, Div Infect Dis, San Diego, CA 92103 USA
[2] Univ Calif San Diego, Dept Neurol, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA
[4] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA
关键词
D O I
10.1086/516141
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Balamuthia mandrillaris, formerly referred to as a leptomyxid ameba, is a free-living ameba that has recently been identified as a cause of meningoencephalitis. Previously, only two genera, Naegleria and Acanthamoeba, were recognized as causes of central nervous system (CNS) infections in humans. In contrast to Naegleria, Balamuthia causes a subacute to-chronic infection of the CNS. Distinct from Acanthamoeba, which appears to favor the immunocompromised host, Balamuthia is capable of infecting both healthy and immunosuppressed hosts. Retrospective analyses as well as an accumulation of newly identified cases have demonstrated that this ameba is an increasingly important pathogen to recognize. We report the isolation, histopathologic features, and confirmation by indirect immunofluorescence of B. mandrillaris in a case of fatal amebic meningoencephalitis.
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收藏
页码:1354 / 1358
页数:5
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