Replication stress: getting back on track

被引：189

作者：

Berti, Matteo ^{[1
]}

Vindigni, Alessandro ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 02期

基金：

美国国家卫生研究院;

关键词：

S-PHASE CHECKPOINT; DNA-DAMAGE TOLERANCE; FORK REVERSAL; MCM2-7; HELICASE; LEADING-STRAND; RESTART; REPAIR; REGRESSION; REPLISOME; TRANSLOCASE;

D O I：

10.1038/nsmb.3163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress-response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.

引用

页码：103 / 109

页数：7

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