Replication stress: getting back on track

被引：188

作者：

Berti, Matteo ^{[1
]}

Vindigni, Alessandro ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 02期

基金：

美国国家卫生研究院;

关键词：

S-PHASE CHECKPOINT; DNA-DAMAGE TOLERANCE; FORK REVERSAL; MCM2-7; HELICASE; LEADING-STRAND; RESTART; REPAIR; REGRESSION; REPLISOME; TRANSLOCASE;

D O I：

10.1038/nsmb.3163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The replication-stress response enables the DNA replication machinery to overcome DNA lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful transmission of genetic information to daughter cells. Multiple replication stress-response pathways have been identified in recent years, thus raising questions about the specific and possibly redundant functions of these pathways. Here, we review the emerging mechanisms of the replication-stress response in mammalian cells and consider how they may influence the dynamics of the core DNA replication complex.

引用

页码：103 / 109

页数：7

共 100 条

[1] Chromosome rearrangements via template switching between diverged repeated sequences [J].

Anand, Ranjith P. ;

Tsaponina, Olga ;

Greenwell, Patricia W. ;

Lee, Cheng-Sheng ;

Du, Wei ;

Petes, Thomas D. ;

Haber, James E. .

GENES & DEVELOPMENT, 2014, 28 (21) :2394-2406

[2] Replication fork reversal and the maintenance of genome stability [J].

Atkinson, John ;

McGlynn, Peter .

NUCLEIC ACIDS RESEARCH, 2009, 37 (11) :3475-3492

[3] Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition [J].

Berti, Matteo ;

Chaudhuri, Arnab Ray ;

Thangavel, Saravanabhavan ;

Gomathinayagam, Shivasankari ;

Kenig, Sasa ;

Vujanovic, Marko ;

Odreman, Federico ;

Glatter, Timo ;

Graziano, Simona ;

Mendoza-Maldonado, Ramiro ;

Marino, Francesca ;

Lucic, Bojana ;

Biasin, Valentina ;

Gstaiger, Matthias ;

Aebersold, Ruedi ;

Sidorova, Julia M. ;

Monnat, Raymond J., Jr. ;

Lopes, Massimo ;

Vindigni, Alessandro .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 20 (03) :347-354

[4] Substrate-Selective Repair and Restart of Replication Forks by DNA Translocases [J].

Betous, Remy ;

Couch, Frank. B. ;

Mason, Aaron C. ;

Eichman, Brandt F. ;

Manosas, Maria ;

Cortez, David .

CELL REPORTS, 2013, 3 (06) :1958-1969

[5] SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication [J].

Betous, Remy ;

Mason, Aaron C. ;

Rambo, Robert P. ;

Bansbach, Carol E. ;

Badu-Nkansah, Akosua ;

Sirbu, Bianca M. ;

Eichman, Brandt F. ;

Cortez, David .

GENES & DEVELOPMENT, 2012, 26 (02) :151-162

[6] PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication [J].

Bianchi, Julie ;

Rudd, Sean G. ;

Jozwiakowski, Stanislaw K. ;

Bailey, Laura J. ;

Soura, Violetta ;

Taylor, Elaine ;

Stevanovic, Irena ;

Green, Andrew J. ;

Stracker, Travis H. ;

Lindsay, Howard D. ;

Doherty, Aidan J. .

MOLECULAR CELL, 2013, 52 (04) :566-573

[7] The Dissolution of Double Holliday Junctions [J].

Bizard, Anna H. ;

Hickson, Ian D. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2014, 6 (07)

[8] Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression [J].

Blastyák, Andras ;

Pintér, Lajos ;

Unk, Ildiko ;

Prakash, Louise ;

Prakash, Satya ;

Haracska, Lajos .

MOLECULAR CELL, 2007, 28 (01) :167-175

[9] Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA [J].

Blastyak, Andras ;

Hajdu, Ildiko ;

Unk, Ildiko ;

Haracska, Lajos .

MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (03) :684-693

[10] DNA Replication: Making Two Forks from One Prereplication Complex [J].

Botchan, Michael ;

Berger, James .

MOLECULAR CELL, 2010, 40 (06) :860-861

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