Human Visual Cortex Responses to Rapid Cone and Melanopsin-Directed Flicker

被引:27
|
作者
Spitschan, Manuel [1 ]
Datta, Ritobrato [2 ]
Stern, Andrew M. [2 ]
Brainard, David H. [1 ]
Aguirre, Geoffrey K. [2 ]
机构
[1] Univ Penn, Dept Psychol, 3401 Walnut St,Suite 400A, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Neurol, 3400 Spruce St, Philadelphia, PA 19104 USA
来源
JOURNAL OF NEUROSCIENCE | 2016年 / 36卷 / 05期
基金
美国国家卫生研究院;
关键词
color vision; flicker; ipRGCs; melanopsin; temporal sensitivity; visual cortex; RETINAL GANGLION-CELLS; COLOR SIGNALS; CENTRAL PROJECTIONS; LIGHT; SENSITIVITY; PUPILLARY; MECHANISMS; OPPONENT; STIMULI; VISION;
D O I
10.1523/JNEUROSCI.1932-15.2016
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Signals from cones are recombined in postreceptoral channels [luminance, L + M; red-green, L - M; blue-yellow, S - (L + M)]. The melanopsin-containing retinal ganglion cells are also active at daytime light levels and recent psychophysical results suggest that melanopsin contributes to conscious vision in humans. Here, we measured BOLD fMRI responses to spectral modulations that separately targeted the postreceptoral cone channels and melanopsin. Responses to spatially uniform (27.5 degrees field size, central 5 degrees obscured) flicker at 0.5, 1, 2, 4, 8, 16, 32, and 64 Hz were recorded from areas V1, V2/V3, motion-sensitive area MT, and the lateral occipital complex. In V1 and V2/V3, higher temporal sensitivity was observed to L + M + S (16 Hz) compared with L - M flicker (8 Hz), consistent with psychophysical findings. Area MT was most sensitive to rapid (32 Hz) flicker of either L + M + S or L - M. We found S cone responses only in areas V1 and V2/V3 (peak frequency: 4 - 8 Hz). In addition, we studied an L + M modulation and found responses that were effectively identical at all temporal frequencies to those recorded for the L + M + S modulation. Finally, we measured the cortical response to melanopsin-directed flicker and compared this response with control modulations that addressed stimulus imprecision and the possibility of stimulation of cones in the shadow of retinal blood vessels (penumbral cones). For our stimulus conditions, melanopsin flicker did not elicit a cortical response exceeding that of the control modulations. We note that failure to control for penumbral cone stimulation could be mistaken for a melanopsin response.
引用
收藏
页码:1471 / 1482
页数:12
相关论文
共 50 条
  • [41] Stimulus-dependence of responses to spatio-temporally modulated flicker stimuli in cat visual cortex
    Kallenbach, U
    Grün, S
    Singer, W
    Munk, MHJ
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 : 283 - 283
  • [42] Retinotopic distribution of chromatic responses in human primary visual cortex
    Vanni, S.
    Henriksson, L.
    Viikari, M.
    James, A. C.
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 24 (06) : 1821 - 1831
  • [43] Dynamics of Contrast Decrement and Increment Responses in Human Visual Cortex
    Norcia, Anthony M.
    Yakovleva, Alexandra
    Hung, Bethany
    Goldberg, Jeffrey L.
    TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2020, 9 (10): : 1 - 17
  • [44] Effects of task and attentional selection on responses in human visual cortex
    Runeson, Erik
    Boynton, Geoffrey M.
    Murray, Scott O.
    JOURNAL OF NEUROPHYSIOLOGY, 2013, 109 (10) : 2606 - 2617
  • [45] Attention modulates responses to motion reversals in human visual cortex
    Tata, Matthew S.
    Mason, Aja L. O.
    Sutherland, Robert J.
    NEUROREPORT, 2007, 18 (13) : 1361 - 1365
  • [46] Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex
    Bednarik, Petr
    Tkac, Ivan
    Giove, Federico
    Eberly, Lynn E.
    Deelchand, Dinesh K.
    Barreto, Felipe R.
    Mangia, Silvia
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2018, 38 (02): : 347 - 359
  • [47] Decoding and Reconstructing Color from Responses in Human Visual Cortex
    Brouwer, Gijs Joost
    Heeger, David J.
    JOURNAL OF NEUROSCIENCE, 2009, 29 (44): : 13992 - 14003
  • [48] Differential Rapid Plasticity in Auditory and Visual Responses in the Primarily Multisensory Orbitofrontal Cortex
    Sharma, Sudha
    Bandyopadhyay, Sharba
    ENEURO, 2020, 7 (03) : 1 - 17
  • [49] Cholinergic Enhancement Reduces Spatial Spread of Visual Responses in Human Early Visual Cortex
    Silver, Michael A.
    Shenhav, Amitai
    D'Esposito, Mark
    NEURON, 2008, 60 (05) : 904 - 914
  • [50] Visual symmetry in the human brain: attentional modulation of fMRI symmetry responses in the visual cortex
    Zamboni, Elisa
    Makin, Alexis D. J.
    Bertamini, Marco
    Morland, Antony B.
    PERCEPTION, 2021, 50 (1_SUPPL) : 21 - 22