Comparative Global Transcription Analysis of Hydrophilic Sapphyrin and Resveratrol on A549 Cell

Anti-cancer agents were studied to use a variety of natural product and chemical synthesis compounds, the effect elucidate cell cycle arrest, growth inhibitor, and death pathway factor expression and so on cancer cell. However molecular mechanisms, by which these anti-cancer agents kill and the extent to which cancer cell, including A549 cell, are resistant remains unclear. In previously DNA microarrays were utilized to analyze the genome-wide transcription changes in A549 cell after anti-cancer compounds (resveratrol, sapphyrin PCI-2050) exposure. In this study, we compared-cell death pathway, cell cycle arrest, growth inhibition and so on-with both gene expression of sapphyrin (PCI-2050) and resveratrol that were treated on A549. And these investigated that resistance to any mechanism to A549 cell. Resveratrol treated A549 cell showed cell death pathway, cell cycle arrest, growth inhibition factor-related gene expression, and sapphyrin treated cell weren't indicated gene expression of cell cycle arrest or growth inhibition. But it exhibited over-expression of c-jun on MAPK (JNK) pathway. Consequently, resveratrol resistance to cancer cell through several apoptotic pathways. But Sapphyrin may estimate to inhibit cancer cell by only certain MAPK (JNK) pathway.