Digital mammography screening: sensitivity of the programme dependent on breast density

被引:75
作者
Weigel, Stefanie [1 ,2 ]
Heindel, W. [1 ,2 ]
Heidrich, J. [3 ]
Hense, H. -W. [3 ,4 ]
Heidinger, O. [3 ]
机构
[1] Univ Munster, Dept Clin Radiol, Albert Schweitzer Campus 1,Bldg A1, D-48149 Munster, Germany
[2] Univ Munster, Reference Ctr Mammog, Albert Schweitzer Campus 1,Bldg A1, D-48149 Munster, Germany
[3] Canc Registry North Rhine Westphalia, Munster, Germany
[4] Univ Munster, Inst Epidemiol & Social Med, Munster, Germany
关键词
Breast cancer screening; Digital mammography; Breast density; Interval cancer; Population surveillance; INTERVAL CANCERS; RISK; WOMEN; ULTRASOUND; IMPACT;
D O I
10.1007/s00330-016-4636-4
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To analyse the impact of breast density on the sensitivity of a population-based digital mammography screening programme (SP) as key evaluation parameter. 25,576 examinations were prospectively stratified from ACR category 1 to 4 for increments of 25 % density during independent double reading. SP was calculated as number of screen-detected cancers divided by the sum of screen-detected plus interval cancers (24-months period) per ACR category, related to the first reading (a), second reading (b) and highest stratification if discrepant (c). Chi-square tests were used for comparison. Overall sensitivity of the programme was 79.9 %. SP in ACR 4 (a: 50 %, b: 50 %, c: 50 %) was significantly lower than in ACR 3 (a: 72.9 %, b: 79.4 %, c: 80.7 %, p < 0.001), ACR 2 (a: 83.9 %, b: 85.7 %, c: 83.2 %, p < 0.001) and ACR 1 (a: 100 %, b: 88.8 %, c: 100 %; p < 0.001). Frequencies of ACR 4 were a: 5.0 %, b: 4.3 %, c: 6.9 %. Digital mammography screening with independent double reading leads to a high overall SP. In the small group of women with breast density classified as ACR 4 SP is significantly reduced compared to all other ACR categories. aEuro cent Overall sensitivity of a population-based digital mammography screening programme (SP) was 79.9 %. aEuro cent In women with ACR 1, 2, or 3, SP ranged between 72.9 %-100 %. aEuro cent ACR 4 was rare in participants (< 7 %) and SP was only 50 %. aEuro cent SP in ACR 4 differed significantly from ACR 3 (p < 0.001).
引用
收藏
页码:2744 / 2751
页数:8
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