Long non-coding RNAs in metabolic disorders: pathogenetic relevance and potential biomarkers and therapeutic targets

被引：16

作者：

Alipoor, B. ^{[1
]}

Nikouei, S. ^{[2
]}

Rezaeinejad, F. ^{[3
]}

Malakooti-Dehkordi, S-N. ^{[4
]}

Sabati, Z. ^{[5
]}

Ghasemi, H. ^{[4
]}

机构：

[1] Yasuj Univ Med Sci, Fac Paramed, Dept Lab Sci, Yasuj, Iran

[2] Yasuj Univ Med Sci, Student Res Comm, Yasuj, Iran

[3] Yasuj Univ Med Sci, Fac Med, Dept Biochem, Yasuj, Iran

[4] Abadan Fac Med Sci, Abadan, Iran

[5] Iran Univ Med Sci, Sch Allied Med Sci, Student Res Comm, Hematol, Tehran, Iran

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2021年 / 44卷 / 10期

关键词：

LncRNAs; Metabolic disorders; Diabetes; Biomarker; FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; COMPETING ENDOGENOUS RNA; HEDGEHOG SIGNALING PATHWAY; CORONARY-ARTERY-DISEASE; DOWN-REGULATION; DIABETES-MELLITUS; LIPID-METABOLISM; ADIPOSE-TISSUE; TRANSCRIPTOME ANALYSIS;

D O I：

10.1007/s40618-021-01559-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background It has been suggested that dysregulation of long non-coding RNAs (lncRNAs) could be associated with the incidence and development of metabolic disorders. Aim Accordingly, this narrative review described the molecular mechanisms of lncRNAs in the development of metabolic diseases including insulin resistance, diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), cirrhosis, and coronary artery diseases (CAD). Furthermore, we investigated the up-to-date findings on the association of deregulated lncRNAs in the metabolic disorders, and potential use of lncRNAs as biomarkers and therapeutic targets. Conclusion LncRNAs/miRNA/regulatory proteins axis plays a crucial role in progression of metabolic disorders and may be used in development of therapeutic and diagnostic approaches.

引用

页码：2015 / 2041

页数：27

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