A facile zirconium(IV) chloride catalysed selective deprotection of t-butyldimethylsilyl (TBDMS) ethers

被引：42
|
作者：
Sharma, GVM [1 ]
Srinivas, B [1 ]
Krishna, PR [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem 3, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 25期
关键词：
TBDMS ethers; zirconium(IV) chloride; desilylation; protecting groups;
D O I：
10.1016/S0040-4039(03)01088-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient protocol for the selective deprotection of t-butyldimethylsilyl (TBDMS) ethers using 20 mol% ZrCl4 in 20-45 min and in high yields, is reported, wherein it is demonstrated that acid and base sensitive groups and allylic and benzylic groups are unaffected. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4689 / 4691
页数：3
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