Lesions in the central amygdala impair sodium intake induced by the blockade of the lateral parabrachial nucleus

被引：21
|
作者：
Andrade-Franze, Glaucia M. F. [1 ]
Andrade, Carina A. F. [2 ]
De Luca, Laurival A., Jr. [1 ]
De Paula, Patricia M. [1 ]
Colombari, Debora S. A. [1 ]
Menani, Jose V. [1 ]
机构：
[1] UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
[2] Fed Univ Alfenas Unifal MG, Dept Biomed Sci, BR-37130000 Alfenas, MG, Brazil
来源：
BRAIN RESEARCH | 2010年 / 1332卷
基金：
巴西圣保罗研究基金会;
关键词：
Sodium appetite; Parabrachial nucleus; Amygdala; Thirst; Muscimol; GABA; SOLITARY TRACT; AREA POSTREMA; SALT APPETITE; NACL INTAKE; RAT; CONNECTIONS; ACTIVATION; MECHANISMS; NEURONS; PROJECTION;
D O I：
10.1016/j.brainres.2010.03.055
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The blockade of the lateral parabrachial nucleus (LPBN) with the GABAergic receptor agonist muscimol induces strong hypertonic NaCl intake in satiated and normovolemic rats, whereas lesions of the central nucleus of the amygdala (CeA) reduce sodium intake induced by different protocols. In the present study we investigated the effects of bilateral lesions of the CeA on water and 0.3 M NaCl intake induced by GABAergic receptor activation with bilateral injections of muscimol into the LPBN in satiated rats. Male Holtzman rats (n=6-10) with bilateral sham or electrolytic lesions (2 mA; 10 s) of the CeA and stainless steel cannulas implanted bilaterally in the LPBN were used. Bilateral injections of muscimol (0.5 nmol/0.2 mu l) into the LPBN in satiated sham-lesioned rats induced 0.3 M NaCl intake (16.1 +/- 5.4 ml/4 h, vs. saline: 1.3 +/- 0.5 ml/4 h) and water intake (8.1 +/- 3.5 ml/4 h, vs. saline: 1.6 +/- 0.5 ml/4 h). Bilateral lesions of the CeA (3 days) abolished 0.3 M NaCl intake (0.1 +/- 0.1 ml/4 h) and water intake (0.1 +/- 0.1 ml/4 h) induced by bilateral injections of muscimol into the LPBN in satiated rats. The present results show that water and 0.3 M NaCl intake induced by the blockade of LPBN neurons with muscimol depends on the integrity of the CeA, suggesting that facilitatory mechanisms present in the CeA are essential for water and hypertonic NaCl intake that arises after the blockade of the inhibitory mechanisms of the LPBN with muscimol. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：57 / 64
页数：8
相关论文
共 50 条
  • [11] Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration
    Kimura, Everton H.
    De Oliveira, Lisandra B.
    Menani, Jose V.
    Callera, Joao C.
    BEHAVIORAL AND BRAIN FUNCTIONS, 2013, 9
  • [12] INHIBITORY EFFECT OF ACTIVATION OF GABAA RECEPTOR IN THE CENTRAL NUCLEUS OF AMYGDALA ON THE SODIUM INTAKE IN THE SODIUM-DEPLETED RAT
    Wang, Q.
    Li, J. R.
    Yang, X. J.
    Chen, K.
    Sun, B.
    Yan, J. Q.
    NEUROSCIENCE, 2012, 223 : 277 - 284
  • [13] SODIUM INTAKE COMBINING CHOLINERGIC ACTIVATION AND NORADRENALINE INTO THE LATERAL PARABRACHIAL NUCLEUS
    Gasparini, S.
    Andrade-Franze, G. M. F.
    Gomide, J. M. C.
    Andrade, C. A. F.
    De Luca, L. A., Jr.
    Colombari, D. S. A.
    De Paula, P. M.
    Colombari, E.
    Menani, J. V.
    NEUROSCIENCE, 2015, 300 : 229 - 237
  • [14] The lateral parabrachial nucleus and central angiotensinergic mechanisms in the control of sodium intake induced by different stimuli
    Roncari, Camila P.
    David, Richard B.
    De Paula, Patricia M.
    Colombari, Debora S. A.
    De Luca, Laurival A., Jr.
    Colombari, Eduardo
    Menani, Jose V.
    BEHAVIOURAL BRAIN RESEARCH, 2017, 333 : 17 - 26
  • [15] AT1 RECEPTOR BLOCKADE IN THE CENTRAL NUCLEUS OF THE AMYGDALA ATTENUATES THE EFFECTS OF MUSCIMOL ON SODIUM AND WATER INTAKE
    Hu, B.
    Qiao, H.
    Sun, B.
    Jia, R.
    Fan, Y.
    Wang, N.
    Lu, B.
    Yan, J. Q.
    NEUROSCIENCE, 2015, 307 : 302 - 310
  • [16] ACTIVATION OF μ-OPIOID RECEPTORS IN THE CENTRAL NUCLEUS OF THE AMYGDALA INDUCES HYPERTONIC SODIUM INTAKE
    Yan, Junbao
    Li, Jinrong
    Yan, Jianqun
    Sun, Huiling
    Wang, Qian
    Chen, Ke
    Sun, Bo
    Wei, Xiaojing
    Song, Lin
    Zhao, Xiaolin
    Wei, Shuangyu
    Han, Ling
    NEUROSCIENCE, 2013, 233 : 28 - 43
  • [17] Serotonergic mechanism of the lateral parabrachial nucleus and relaxin-induced sodium intake
    Menani, JV
    Barbosa, SP
    McKinley, MJ
    Wade, JD
    De Luca, LA
    BRAIN RESEARCH, 2004, 1030 (01) : 74 - 80
  • [18] MOXONIDINE INTO THE LATERAL PARABRACHIAL NUCLEUS MODIFIES POSTINGESTIVE SIGNALS INVOLVED IN SODIUM INTAKE CONTROL
    Gasparini, S.
    Menani, J. V.
    Daniels, D.
    NEUROSCIENCE, 2015, 284 : 768 - 774
  • [19] Purinergic mechanisms of lateral parabrachial nucleus facilitate sodium depletion-induced NaCl intake
    Menezes, Miguel F.
    Barbosa, Silas P.
    De Andrade, Carina A. F.
    Menani, Jose V.
    De Paula, Patricia M.
    BRAIN RESEARCH, 2011, 1372 : 49 - 58
  • [20] Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake
    De Gobbi, JIF
    De Luca, LA
    Menani, JV
    BRAIN RESEARCH, 2000, 880 (1-2) : 131 - 138
12345