Tirucallane-Type Triterpenoids from the Fruit of Ficus carica and Their Cytotoxic Activity

被引：17

作者：

Jing, Lin ^{[1
]}

Zhang, Yang-Mei ^{[1
]}

Luo, Jian-Guang ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2015年 / 63卷 / 03期

关键词：

Ficus carica; tirucallane triterpenoid; cytotoxicity; fruit; Moraceae; LATEX;

D O I：

10.1248/cpb.c14-00779

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine new tirucallane-type triterpenoids, ficutirucins A-I (1-9), were isolated from the fruit of Ficus carica. Their structures were established on the basis of spectroscopic data and chemical methods. All isolates were evaluated for their cytotoxic activities against three human cancer cell lines, MCF-7, HepG-2, and U2OS. Compounds 1-3, 6, 7, and 9 exhibited moderate cytotoxic activities with IC50 values of 11.67-45.61, mu M against one or more of the three cancer cell lines.

引用

页码：237 / 243

页数：7

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