Manganese-Catalyzed ortho-Alkenylation of Aromatic Amidines with Alkynes via C-H Activation

被引：20
|
作者：
Jia, Teng [1 ,2 ]
Wang, Congyang [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Inst Chem, Beijing Natl Lab Mol Sci,CAS Key Lab Mol Recognit, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Huairou Natl Comprehens Sci Ctr, Phys Sci Lab, Beijing 101400, Peoples R China
来源：
CHEMCATCHEM | 2019年 / 11卷 / 21期
基金：
中国国家自然科学基金;
关键词：
alkenylation; C-H activation; manganese; amidines; stereoselectivity; EXPEDIENT ACCESS; DIRECTING GROUPS; RELAY CATALYSIS; 4+2 ANNULATION; BOND FORMATION; FUNCTIONALIZATION; ESTERS; ISOQUINOLINES; ALLYLATION; ALDEHYDES;
D O I：
10.1002/cctc.201900387
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The first ortho-alkenylation of aromatic amidines with alkynes was realized by earth-abundant manganese catalysis through C-H activation. A catalytic amount of PhMgBr was found essential for improved efficiency of this transformation. Wide tolerance of functional groups and excellent E/Z selectivity highlighted the current protocol.
引用
收藏
页码：5292 / 5295
页数：4
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