PELP1: Structure, biological function and clinical significance

被引：38
作者：
Sareddy, Gangadhara Reddy [1 ]
Vadlamudi, Ratna K. [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA
来源：
GENE | 2016年 / 585卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Nuclear receptor; Estrogen receptor; Transcriptional activation; Hormonal action; Signal transduction; Coregulator; PELP1; GLUTAMIC-ACID-RICH; RECEPTOR COACTIVATOR PELP1/MNAR; GROWTH-FACTOR REGULATION; ESTROGEN-RECEPTOR; BREAST-CANCER; ANDROGEN RECEPTOR; PROLINE-RICH; ONCOGENIC FUNCTIONS; PROGNOSTIC-SIGNIFICANCE; NONGENOMIC ACTIVITY;
D O I：
10.1016/j.gene.2016.03.017
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein that functions as a coregulator of several transcription factors and nuclear receptors. Notably, the PELP1 protein has a histone-binding domain, recognizes histone modifications and interacts with several chromatin-modifying complexes. PELP1 serves as a substrate of multitude of kinases, and phosphorylation regulates its functions in various complexes. Further, PELP1 plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response. PELP1 expression is upregulated in several cancers, its deregulation contributes to therapy resistance, and it is a prognostic biomarker for breast cancer survival. Recent evidence suggests that PELP1 represents a novel therapeutic target for many hormonal cancers. In this review, we summarized the emerging biological properties and functions of PELP1. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：128 / 134
页数：7
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