What is a resistance gene? Ranking risk in resistomes

被引：687
作者：
Martinez, Jose L. [1 ,2 ]
Coque, Teresa M. [2 ,3 ]
Baquero, Fernando [2 ,3 ]
机构：
[1] CSIC, Ctr Nacl Biotecnol, Dept Biotecnol Microbiana, Madrid 28049, Spain
[2] CSIC, Unidad Resistencia Antibiot & Virulencia Bacteria, Madrid 28049, Spain
[3] Hosp Univ Ramon & Cajal, Dept Microbiol, Inst Ramon & Cajal Invest Sanitaria IRYCIS, Madrid 28034, Spain
来源：
NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 02期
关键词：
ANTIBIOTIC-RESISTANCE; EFFLUX PUMPS; EVOLUTION; SUSCEPTIBILITY; DETERMINANTS; VANCOMYCIN; PENICILLIN; INTERPLAY; RESERVOIR; BACTERIA;
D O I：
10.1038/nrmicro3399
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the environment, which has led to the suggestion that there is a high risk that these genes will spread to bacteria that cause human infections. If this is true, estimating the real risk of dissemination of resistance genes from environmental reservoirs to human pathogens is therefore very difficult. In this Opinion article, we analyse the current definitions of antibiotic resistance and antibiotic resistance genes, and we describe the bottlenecks that affect the transfer of antibiotic resistance genes to human pathogens. We propose rules for estimating the risks associated with genes that are present in environmental resistomes by evaluating the likelihood of their introduction into human pathogens, and the consequences of such events for the treatment of infections.
引用
收藏
页码：116 / 123
页数：8
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