Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

被引：1604

作者：

Mucida, Daniel ^{[1
]}

Park, Yunji ^{[1
]}

Kim, Gisen ^{[1
]}

Turovskaya, Olga ^{[1
]}

Scott, Iain ^{[1
]}

Kronenberg, Mitchell ^{[1
]}

Cheroutre, Hilde ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USA

来源：

SCIENCE | 2007年 / 317卷 / 5835期

关键词：

TGF-BETA; INFLAMMATION; GENERATION; FOXP3;

D O I：

10.1126/science.1145697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cytokine transforming growth factor-beta (TGF-beta) converts naive T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-beta has also been found to promote the differentiation of naive T lymphocytes into proinflammatory IL-17 cytokine-producing T helper 17 (TH17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-beta can generate such distinct outcomes. We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-beta-dependent immune responses, capable of inhibiting the IL-6-driven induction of proinflammatory TH17 cells and promoting anti-inflammatory Treg cell differentiation. These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity.

引用

页码：256 / 260

页数：5

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