Viral epitope-specific T cell responses induced in chronic, hepatitis C virus-infected patients

被引:1
|
作者
Fast, Loren D.
Mishra, Sasmita
Promrat, Kittichai
Losikoff, Phyllis T.
Gregory, Stephen H. [1 ]
机构
[1] Brown Univ, Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA
基金
美国国家卫生研究院;
关键词
HCV; Human; Peptide; T lymphocyte; Vaccine; DENDRITIC CELLS;
D O I
10.1016/j.dld.2017.02.005
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Approximate 180 million people worldwide are infected with hepatitis C virus (HCV). Historically, vaccination has been the most effective strategy for controlling infections of such major health concern. Therapeutic vaccine strategies for HCV, however, have demonstrated negligible success. Aim: Demonstrate the ability of highly-conserved viral epitopes to overcome the immune dysfunction often associated with chronic HCV infections. Methods: T cells from five chronic, HCV-infected patients were immunophenotyped by flow cytometry. The ex vivo T cell responses to highly-conserved viral epitopes were assessed by ELISpot assay and cytokine bead array analysis. Results: Both HLA-DRB-1-and HLA-A2-restricted viral epitopes induced specific, TH1-type cytokine production by T cells derived from the patients. Induction occurred despite expression of cell-surface inhibitory molecules and the presence of regulatory T cells. Conclusion: These findings support the potential ability of a broad, multi-epitope-based therapeutic vaccine to elicit virus-specific immune responses in chronic hepatitis C virus-infected patients. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:709 / 713
页数:5
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