The Expression of Brain-Derived Neurotrophic Factor and Tryptophan Hydroxylase in the Dorsal Raphe Nucleus during Repeated Stress

被引：0
作者：
Shishkina, G. T. [1 ]
Bulygina, V. V. [1 ]
Agarina, N. P. [1 ]
Dygalo, N. N. [1 ]
机构：
[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia
来源：
NEUROCHEMICAL JOURNAL | 2018年 / 12卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
brain-derived neurotrophic factor; tryptophan hydroxylase; dorsal raphe nucleus; stress; SEROTONIN; BDNF; DEPRESSION; VULNERABILITY; NEUROGENESIS;
D O I：
10.1134/S1819712418020101
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The mechanisms of development of stress-induced depression symptoms may include interaction between the elements of the serotonergic (5-HT) system and brain-derived neurotrophic factor (BDNF) at the level of the cell bodies of 5-HT neurons. In order to evaluate this situation, we used immunofluorescent staining of BDNF protein and the enzyme of serotonin synthesis tryptophan hydroxylase (TPH) in the dorsal raphe nucleus (DRN) of adult male rats that were subjected daily to a 15-min forced swim stress for 1, 2, 7, or 14 days. The expression of the BDNF protein was substantially decreased in the DRN after 7- or 14-day stress, whereas the expression of the TPH protein significantly increased after the 14-day stress and did not differ from the control after the shorter duration of repeated stress. The absence of correlation between some indices indicates their independence from each other at the level of the cell bodies of 5-HT neurons.
引用
收藏
页码：152 / 154
页数：3
相关论文
共 22 条
[1]   TrkB Signaling in Dorsal Raphe Nucleus is Essential for Antidepressant Efficacy and Normal Aggression Behavior [J].
Adachi, Megumi ;
Autry, Anita E. ;
Mahgoub, Melissa ;
Suzuki, Kanzo ;
Monteggia, Lisa M. .
NEUROPSYCHOPHARMACOLOGY, 2017, 42 (04) :886-894
[2]   Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: Major depression and suicide [J].
Bach-Mizrachi, H ;
Underwood, MD ;
Kassir, SA ;
Bakalian, MJ ;
Sibille, E ;
Tamir, H ;
Mann, JJ ;
Arango, V .
NEUROPSYCHOPHARMACOLOGY, 2006, 31 (04) :814-824
[3]   Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone [J].
Banasr, M ;
Hery, M ;
Printemps, R ;
Daszuta, A .
NEUROPSYCHOPHARMACOLOGY, 2004, 29 (03) :450-460
[4]   More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides [J].
Boldrini, M ;
Underwood, MD ;
Mann, JJ ;
Arango, V .
BRAIN RESEARCH, 2005, 1041 (01) :19-28
[5]   Downregulation of Serotonergic Gene Expression in the Raphe Nuclei of the Midbrain Under Chronic Social Defeat Stress in Male Mice [J].
Boyarskikh, Ul'yana A. ;
Bondar, Natalya P. ;
Filipenko, Maxim L. ;
Kudryavtseva, Natalia N. .
MOLECULAR NEUROBIOLOGY, 2013, 48 (01) :13-21
[6]   Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis [J].
Donner, Nina C. ;
Siebler, Philip H. ;
Johnson, Dante T. ;
Villarreal, Marcos D. ;
Mani, Sofia ;
Matti, Allison J. ;
Lowry, Christopher A. .
PSYCHONEUROENDOCRINOLOGY, 2016, 63 :178-190
[7]   A neurotrophic model for stress-related mood disorders [J].
Duman, Ronald S. ;
Monteggia, Lisa M. .
BIOLOGICAL PSYCHIATRY, 2006, 59 (12) :1116-1127
[8]   The serotonin-BDNF duo: Developmental implications for the vulnerability to psychopathology [J].
Homberg, Judith Regina ;
Molteni, Raffaella ;
Calabrese, Francesca ;
Riva, Marco A. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2014, 43 :35-47
[9]   Serotonergic vulnerability and depression: assumptions, experimental evidence and implications [J].
Jans, L. A. W. ;
Riedel, W. J. ;
Markus, C. R. ;
Blokland, A. .
MOLECULAR PSYCHIATRY, 2007, 12 (06) :522-543
[10]   Effects of chronic forced-swim stress on behavioral properties in rats with neonatal repeated MK-801 treatment [J].
Kawabe, Kouichi .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2017, 159 :48-54
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