The diagnostic and prognostic value of brain natriuretic peptide and aminoterminal (nt)-pro brain natriuretic peptide

被引：28
作者：
Weber, T [1 ]
Auer, J [1 ]
Eber, B [1 ]
机构：
[1] Gen Hosp Kreuzschwestern, Dept Cardiol, A-4600 Wels, Austria
来源：
CURRENT PHARMACEUTICAL DESIGN | 2005年 / 11卷 / 04期
关键词：
natriuretic peptides; heart failure; prognosis; acute coronary syndromes;
D O I：
10.2174/1381612053382034
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The discovery of B-type natriuretic peptide (BNP) and n-terminal pro BNP (nt-proBNP) as markers for the diagnosis, severity and prognosis of patients with congestive heart failure has been called a true breakthrough for patients and physicians faced with this disorder. Moreover, the literature on their prognostic value in other clinical conditions like acute coronary syndromes, right-sided heart failure and even in the general population is rapidly growing. This review aims to sort out the current evidence on the clinical utility of the natriuretic peptides with a focus on their diagnostic and prognostic values. With respect to their diagnostic properties, the test is best used to rule out heart failure in patients with acute dyspnoe, because low levels of these neurohormones in this clinical context make the presence of heart failure very unlikely. In patients with elevated values of BNP or nt-proBNP, further cardiological assessment is necessary, as their plasma levels are affected not only by left ventricular function.
引用
收藏
页码：511 / 525
页数：15
相关论文
共 98 条
[51]   Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure [J].
Maisel, AS ;
Krishnaswamy, P ;
Nowak, RM ;
McCord, J ;
Hollander, JE ;
Duc, P ;
Omland, T ;
Storrow, AB ;
Abraham, WT ;
Wu, AHB ;
Clopton, P ;
Steg, PG ;
Westheim, A ;
Knudsen, CW ;
Perez, A ;
Kazanegra, R ;
Herrmann, HC ;
McCullough, PA .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (03) :161-167
[52]   INCREASED SECRETION OF ATRIAL AND BRAIN NATRIURETIC PEPTIDES DURING ACUTE MYOCARDIAL-ISCHEMIA INDUCED BY DYNAMIC EXERCISE IN PATIENTS WITH ANGINA-PECTORIS [J].
MARUMOTO, K ;
HAMADA, M ;
HIWADA, K .
CLINICAL SCIENCE, 1995, 88 (05) :551-556
[53]   Prognostic value of repeated 123I-metaiodobenzylguanidine imaging in patients with dilated cardiomyopathy with congestive heart failure before and after optimized treatments -: Comparison with neurohumoral factors [J].
Matsui, T ;
Tsutamoto, T ;
Maeda, K ;
Kusukawa, J ;
Kinoshita, M .
CIRCULATION JOURNAL, 2002, 66 (06) :537-543
[54]  
McCullough PA, 2003, J AM COLL CARDIOL, V41, p278A
[55]  
McCullough Peter A, 2003, Rev Cardiovasc Med, V4 Suppl 4, pS13
[56]   Biochemical detection of left-ventricular systolic dysfunction [J].
McDonagh, TA ;
Robb, SD ;
Murdoch, DR ;
Morton, JJ ;
Ford, I ;
Morrison, CE ;
Tunstall-Pedoe, H ;
McMurray, JJV ;
Dargie, HJ .
LANCET, 1998, 351 (9095) :9-13
[57]   Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population [J].
McDonagh, TA ;
Cunningham, AD ;
Morrison, CE ;
McMurray, JJV ;
Ford, I ;
Morton, JJ ;
Dargie, HJ .
HEART, 2001, 86 (01) :21-26
[58]   Comparison of candesartan, enalapril, and their combination in congestive heart failure - Randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study - The RESOLVD pilot study investigators [J].
McKelvie, RS ;
Yusuf, S ;
Pericak, D ;
Avezum, A ;
Burns, RJ ;
Probstfield, J ;
Tsuyuki, RT ;
White, M ;
Rouleau, J ;
Latini, R ;
Maggioni, A ;
Young, J ;
Pogue, J .
CIRCULATION, 1999, 100 (10) :1056-1064
[59]   Atrial and brain natriuretic peptides as markers of response to resynchronisation therapy [J].
Molhoek, SG ;
Bax, JJ ;
van Erven, L ;
Bootsma, M ;
Steendijk, P ;
Lentjes, E ;
Boersma, E ;
van der Laarse, A ;
van der Wall, EE ;
Schalij, MJ .
HEART, 2004, 90 (01) :97-98
[60]   INCREASED PLASMA-LEVELS OF BRAIN NATRIURETIC PEPTIDE IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION [J].
MORITA, E ;
YASUE, H ;
YOSHIMURA, M ;
OGAWA, H ;
JOUGASAKI, M ;
MATSUMURA, T ;
MUKOYAMA, M ;
NAKAO, K .
CIRCULATION, 1993, 88 (01) :82-91
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