Encapsulation and controlled release of an antimalarial drug using surface functionalized mesoporous silica nanocarriers

被引：7

作者：

Hirayama, Haruka ^{[1
]}

Amolegbe, Saliu Alao ^{[2
]}

Islam, Md Saidul ^{[1
,3
]}

Rahman, Mohammad Atiqur ^{[1
]}

Goto, Nonoka ^{[1
]}

Sekine, Yoshihiro ^{[1
,4
]}

Hayami, Shinya ^{[1
,3
]}

机构：

[1] Kumamoto Univ, Grad Sch Sci & Technol, Dept Chem, Chuo Ku, 2-39-1 Kurokami, Kumamoto 8608555, Japan

[2] Fed Univ Agr, Coll Phys Sci, Dept Chem, Abeokuta FUNAAB, Abeokuta 2240, Nigeria

[3] Kumamoto Univ, Inst Ind Nanomat IINa, Chuo Ku, 2-39-1 Kurokami, Kumamoto 8608555, Japan

[4] Kumamoto Univ, Prior Org Innovat & Excellence, Chuo Ku, 2-39-1 Kurokami, Kumamoto 8608555, Japan

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 25期

关键词：

ORAL BIOAVAILABILITY; GUEST MOLECULES; NANOPARTICLES; DELIVERY;

D O I：

10.1039/d1tb00954k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Herein, we report the encapsulation and release of antimalarial drug quinine (QN) using three nanocarriers, including MCM-41 (1), and its 3-aminopropyl silane (aMCM-41 (2)) and 3-phenylpropyl silane (pMCM-41 (3)) surface functionalized derivatives. The pH and thermal optimization effects on QN adsorption and release from 1, 2 and 3 were investigated.

引用

页码：5043 / 5046

页数：4

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