Inhibitory effects of tyrosine kinase inhibitors on capacitative Ca2+ entry in rat glioma C6 cells

被引：5
|
作者：
Takemura, H
Sakano, S
Kaneko, M
Ohshika, H
机构：
[1] Sapporo Med Univ, Sch Med, Dept Pharmacol, Sapporo, Hokkaido 060, Japan
[2] Sapporo Med Univ, Sch Med, Dept Traumatol & Crit Care Med, Sapporo, Hokkaido 060, Japan
来源：
LIFE SCIENCES | 1998年 / 62卷 / 16期
关键词：
glioma cells; capacitative Ca2+ entry; thapsigargin; tyrosine kinase inhibitor;
D O I：
10.1016/S0024-3205(98)00086-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of genistein and erbstatin analogue, inhibitors of tyrosine kinase, on Ca2+ mobilization evoked by thapsigargin (TG) were examined in rat glioma C6 cells. Genistein and erbstatin analogue inhibited the Ca2+ release from intracellular pools as well as Ca2+ entry from extracellular medium evoked by TG in a dose-dependent manner. However, they did not affect a Ca2+ entry due to leakage of Ca2+ from extracellular medium into cells. The present results suggest that tyrosine kinase inhibitors inhibit capacitative Ca2+ entry due to the inhibition of both Ca2+ entry itself and Ca-2+ release in rat glioma C6 cells. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：PL271 / PL276
页数：6
相关论文
共 50 条
  • [41] The Inhibitory Mechanisms of the Tyrosine Kinase Inhibitors Herbimycin A, Genistein, and Tyrphostin B48 with Regard to the Function of the Aryl Hydrocarbon Receptor in Caco-2 Cells
    Kasai, Shuya
    Kikuchi, Hideaki
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2010, 74 (01) : 36 - 43
  • [42] Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells
    Qian, Yongchang
    Falahatpisheh, M. Hadi
    Zheng, Ying
    Ramos, Kenneth S.
    Tiffany-Castiglioni, Evelyn
    NEUROTOXICITY RESEARCH, 2001, 3 (06) : 581 - 589
  • [43] Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells
    Yongchang Qian
    M. Hadi Falahatpisheh
    Ying Zheng
    Kenneth S. Ramos
    Evelyn Tiffany-Castiglioni
    Neurotoxicity Research, 2001, 3 : 581 - 589
  • [44] RAT MITOGEN-STIMULATED LYMPHOKINE-ACTIVATED T-KILLER CELLS - PRODUCTION AND EFFECTS ON C-6 GLIOMA-CELLS INVITRO AND INVIVO IN THE BRAIN OF WISTAR RATS
    CARSON, WE
    JAKOWATZ, JG
    YAMAMOTO, R
    FITZGERALD, T
    GUPTA, S
    VAYUVEGULA, B
    LUCCI, JA
    BECKMAN, MT
    DULKANCHAINUN, S
    GRANGER, GA
    JEFFES, EWB
    JOURNAL OF IMMUNOTHERAPY, 1991, 10 (02) : 131 - 140
  • [45] Resveratrol mobilizes Ca2+ from intracellular stores and induces c-Jun N-terminal kinase activation in tumoral AR42J cells
    Garcia-Sanchez, Lourdes
    Santofimia-Castano, Patricia
    Miro-Moran, Alvaro
    Tapia, Jose A.
    Salido, Gines M.
    Gonzalez, Antonio
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2012, 362 (1-2) : 15 - 23
  • [46] Concerted action of cytosolic Ca2+ and protein kinase C in receptor-mediated phospholipase D activation in Chinese hamster ovary cells expressing the cholecystokinin-A receptor
    Bosch, RR
    Smeets, RLL
    Sleutels, F
    Patel, AMP
    Vries, SEV
    de Pont, JJHHM
    Willems, PHGM
    BIOCHEMICAL JOURNAL, 1999, 337 : 263 - 268
  • [47] S100B-p53 disengagement by pentamidine promotes apoptosis and inhibits cellular migration via aquaporin-4 and metalloproteinase-2 inhibition in C6 glioma cells
    Capoccia, Elena
    Cirillo, Carla
    Marchetto, Annalisa
    Tiberi, Samanta
    Sawikr, Youssef
    Pesce, Marcella
    D'Alessandro, Alessandra
    Scuderi, Caterina
    Sarnelli, Giovanni
    Cuomo, Rosario
    Steardo, Luca
    Esposito, Giuseppe
    ONCOLOGY LETTERS, 2015, 9 (06) : 2864 - 2870
  • [48] Muscarinic Acetylcholine Receptors Potentiate 5′-Adenosine Monophosphate-Activated Protein Kinase Stimulation and Glucose Uptake Triggered by Thapsigargin-Induced Store-Operated Ca2+ Entry in Human Neuroblastoma Cells
    Olianas, Maria C.
    Dedoni, Simona
    Onali, Pierluigi
    NEUROCHEMICAL RESEARCH, 2018, 43 (02) : 245 - 258
  • [49] Muscarinic Acetylcholine Receptors Potentiate 5′-Adenosine Monophosphate-Activated Protein Kinase Stimulation and Glucose Uptake Triggered by Thapsigargin-Induced Store-Operated Ca2+ Entry in Human Neuroblastoma Cells
    Maria C. Olianas
    Simona Dedoni
    Pierluigi Onali
    Neurochemical Research, 2018, 43 : 245 - 258
  • [50] EFFECTS OF HERBIMYCIN-A AND ST638 ON FC-EPSILON RECEPTOR-MEDIATED HISTAMINE-RELEASE AND CA2+ SIGNALS IN RAT BASOPHILIC LEUKEMIA (RBL-2H3) CELLS
    TESHIMA, R
    IKEBUCHI, H
    SAWADA, J
    FURUNO, T
    NAKANISHI, M
    TERAO, T
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1994, 1221 (01): : 37 - 46
12345