Inhibitory effects of tyrosine kinase inhibitors on capacitative Ca2+ entry in rat glioma C6 cells

被引：5

作者：

Takemura, H

Sakano, S

Kaneko, M

Ohshika, H

机构：

[1] Sapporo Med Univ, Sch Med, Dept Pharmacol, Sapporo, Hokkaido 060, Japan

[2] Sapporo Med Univ, Sch Med, Dept Traumatol & Crit Care Med, Sapporo, Hokkaido 060, Japan

来源：

LIFE SCIENCES | 1998年 / 62卷 / 16期

关键词：

glioma cells; capacitative Ca2+ entry; thapsigargin; tyrosine kinase inhibitor;

D O I：

10.1016/S0024-3205(98)00086-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of genistein and erbstatin analogue, inhibitors of tyrosine kinase, on Ca2+ mobilization evoked by thapsigargin (TG) were examined in rat glioma C6 cells. Genistein and erbstatin analogue inhibited the Ca2+ release from intracellular pools as well as Ca2+ entry from extracellular medium evoked by TG in a dose-dependent manner. However, they did not affect a Ca2+ entry due to leakage of Ca2+ from extracellular medium into cells. The present results suggest that tyrosine kinase inhibitors inhibit capacitative Ca2+ entry due to the inhibition of both Ca2+ entry itself and Ca-2+ release in rat glioma C6 cells. (C) 1998 Elsevier Science Inc.

引用

页码：PL271 / PL276

页数：6

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