Inhibitory effects of tyrosine kinase inhibitors on capacitative Ca2+ entry in rat glioma C6 cells

被引：5
|
作者：
Takemura, H
Sakano, S
Kaneko, M
Ohshika, H
机构：
[1] Sapporo Med Univ, Sch Med, Dept Pharmacol, Sapporo, Hokkaido 060, Japan
[2] Sapporo Med Univ, Sch Med, Dept Traumatol & Crit Care Med, Sapporo, Hokkaido 060, Japan
来源：
LIFE SCIENCES | 1998年 / 62卷 / 16期
关键词：
glioma cells; capacitative Ca2+ entry; thapsigargin; tyrosine kinase inhibitor;
D O I：
10.1016/S0024-3205(98)00086-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of genistein and erbstatin analogue, inhibitors of tyrosine kinase, on Ca2+ mobilization evoked by thapsigargin (TG) were examined in rat glioma C6 cells. Genistein and erbstatin analogue inhibited the Ca2+ release from intracellular pools as well as Ca2+ entry from extracellular medium evoked by TG in a dose-dependent manner. However, they did not affect a Ca2+ entry due to leakage of Ca2+ from extracellular medium into cells. The present results suggest that tyrosine kinase inhibitors inhibit capacitative Ca2+ entry due to the inhibition of both Ca2+ entry itself and Ca-2+ release in rat glioma C6 cells. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：PL271 / PL276
页数：6
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