Zinc Influences Innate Immune Responses in Children with Enterotoxigenic Escherichia coli-Induced Diarrhea

被引：54

作者：

Sheikh, Alaullah ^{[1
]}

Shamsuzzaman, Sohel ^{[2
]}

Ahmad, Shaikh Meshbahuddin ^{[1
]}

Nasrin, Dilruba ^{[3
]}

Nahar, Setarun ^{[1
]}

Alam, Mohammad Murshid ^{[1
]}

Al Tarique, Abdullah ^{[1
]}

Begum, Yasmin Ara ^{[1
]}

Qadri, Syed Saleheen ^{[2
]}

Chowdhury, Mohiul Islam ^{[1
]}

Saha, Amit ^{[1
]}

Larson, Charles P. ^{[4
]}

Qadri, Firdausi ^{[1
]}

机构：

[1] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh

[2] Univ Dhaka, Dept Biochem & Mol Biol, Dhaka 1000, Bangladesh

[3] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[4] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1W5, Canada

来源：

JOURNAL OF NUTRITION | 2010年 / 140卷 / 05期

关键词：

ORAL CHOLERA VACCINE; SUBUNIT-WHOLE-CELL; CONTROLLED-TRIAL; BANGLADESHI CHILDREN; COLONIZATION FACTORS; DEVELOPING-COUNTRIES; ANTIBODY-RESPONSE; CONJUGATE VACCINE; YOUNG-CHILDREN; SUPPLEMENTATION;

D O I：

10.3945/jn.109.111492

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Information is limited on the effect of zinc on immune responses in children with diarrhea due to enterotoxigenic Escherichia coli (ETEC), the most common bacterial pathogen in children. We studied the immunological effect of zinc treatment (20 mg/d) and supplementation (10 mg/d) in children with diarrhea due to ETEC. A total of 148 children aged 6-24 mo were followed up for 9 mo after a 10-d zinc treatment (ZT; n = 74) or a 10-d zinc treatment plus 3-mo supplementation (ZT+S; n = 74), as well as 50 children with ETEC-induced diarrhea that were not treated with zinc (UT). Fifty control children (HC) of the same age group from the same location were also studied. Serum zinc concentrations were higher in both the ZT (P < 0.001) and ZT+S groups (P < 0.001) than in the UT group but did not differ from the HC group. We found higher serum complement C3 immediately after zinc administration in both ZT (P < 0.001) and ZT+S (P < 0.001) groups than in the UT group. Phagocytic activity in children in both ZT (P < 0.01) and ZT+S (P < 0.01) groups was greater than in the UT group. However, oxidative burst capacity was lower in zinc-receiving groups (ZT, P < 0.001 and ZT+S, P < 0.001) than in the UT group. The naive:memory T cell ratio in both ZT (P < 0.05) and ZT+S (P < 0.01) groups was higher than in the UT group from d 2 to 15. Increased responses, including complement C3, phagocytic activity, and changes in T cell phenotypes, suggest that zinc administration enhances innate immunity against ETEC infection in children. J. Nutr. 140: 1049-1056, 2010.

引用

页码：1049 / 1056

页数：8

共 46 条

[1] Enhanced immunogenicity of an oral inactivated cholera vaccine in infants in Bangladesh obtained by zinc supplementation and by temporary withholding breast-feeding [J].