B.1.617.2 (Delta) Variant of SARS-CoV-2: features, transmission and potential strategies

被引：39
作者：
Zhan, Yan [1 ,2 ,3 ,4 ,5 ]
Yin, Hui [1 ,2 ,3 ,4 ,5 ]
Yin, Ji-Ye [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410078, Peoples R China
[2] Cent South Univ, Inst Clin Pharmacol, Changsha 410078, Peoples R China
[3] Hunan Key Lab Pharmacogenet, Changsha 410078, Peoples R China
[4] Engn Res Ctr Appl Technol Pharmacogen, Minist Educ, 110 Xiangya Rd, Changsha 410078, Peoples R China
[5] Natl Clin Res Ctr Geriatr Disorders, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
[6] Hunan Key Lab Precise Diag & Treatment Gastrointe, Changsha 410078, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Key words; COVID-19; B; 1; 617; 2; Delta variants; SARS-CoV-2; transmission; vaccines; diagnosis; structural biology; immune; escape; VACCINE; EMERGENCE; B.1.1.7; SPIKE;
D O I：
10.7150/ijbs.66881
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic. With the continuous evolution of the viral genome, SARS-CoV-2 has evolved many variants. B.1.617.2, also called Delta, is one of the most concerned variants. The Delta variant was first reported in India at the end of 2020 but has spread globally, by now, to 135 countries and is not stand still. Delta shared some mutations with other variants, and owned its special mutations on spike proteins, which may be responsible for its strong transmission and increasing virulence. Under these circumstances, a systematic summary of Delta is necessary. This review will focus on the Delta variant. We will describe all the characteristics of Delta (including biological features and clinical characteristics), analyze potential reasons for its strong transmission, and provide potential protective ways for combating Delta.
引用
收藏
页码：1844 / 1851
页数：8
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