Surface Segregation Assessment in Poly(ε-caprolactone)-poly(ethylene glycol) Multiblock Copolymer Films

被引：17

作者：

Cometa, Stefania ^{[1
]}

Chiellini, Federica ^{[1
]}

Bartolozzi, Irene ^{[1
]}

Chiellini, Emo ^{[1
]}

De Giglio, Elvira ^{[2
]}

Sabbatini, Luigia ^{[2
]}

机构：

[1] Univ Pisa, Lab Bioact Polymer Mat Biomed & Environm Applicat, Dept Chem & Ind Chem, UdR INSTM, I-56010 Pisa, Italy

[2] Univ Bari, Dept Chem, I-70126 Bari, Italy

来源：

MACROMOLECULAR BIOSCIENCE | 2010年 / 10卷 / 03期

关键词：

biocompatibility; block copolymers; supports; surfaces; X-ray; RAY PHOTOELECTRON-SPECTROSCOPY; BLOCK-COPOLYMERS; MICROPHASE SEPARATION; POLY(ETHYLENE GLYCOL); POLYMER SURFACES; BIOCOMPATIBILITY; SCIENCE; PEG; XPS; RELEASE;

D O I：

10.1002/mabi.200900284

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability to predict the in vivo performance of multiblock-copolymer-based biomaterials is crucial for their applicability in the biomedical field. In this work, XPS analysis of PCL-PEG copolymers was carried out, as well as morphological and wettability evaluations by SEM and CA measurements, respectively. XPS analysis on films equilibrated in PBS demonstrated a further enrichment in the PEG component on the surface. Copolymer films obtained by casting using different solvents showed a dependence in segregation according to the solvent employed. Cell adhesion tests demonstrated the importance of copolymer segregation and rearrangement in a wet environment, with a dependence of these phenomena on the copolymer molecular weight.

引用

页码：317 / 327

页数：11

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