Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines

被引：7

作者：

Saito, Susumu ^{[1
,2
,3
,6
]}

Kitamura-Muramatsu, Yuri ^{[1
]}

Komine, Fumiko ^{[1
]}

Polat, Meripet ^{[2
,4
]}

Takeshima, Shin-nosuke ^{[2
,3
,5
]}

Takei, Masami ^{[6
]}

Aida, Yoko ^{[2
,4
,6
]}

机构：

[1] RIKEN GENESIS CO LTD, Life Innovat Ctr, Kawasaki Ku, 3F,3-25-22 Tonomachi, Kawasaki, Kanagawa 2100821, Japan

[2] RIKEN, Viral Infect Dis Unit, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[3] RIKEN, Ctr Adv Photon, Photon Control Technol Team, Wako, Saitama, Japan

[4] RIKEN Cluster Sci Technol & Innovat Hub, Baton Zone Program, Nakamura Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[5] Jumonji Univ, Fac Human Life, Dept Food & Nutr, 2-1-28 Sugasawa, Saitama 3520017, Japan

[6] Nihon Univ, Sch Med, Dept Med, Div Hematol & Rheumatol,Itabashi Ku, 30-1 Oyaguchi Kami Cho, Tokyo 1738610, Japan

来源：

ARCHIVES OF VIROLOGY | 2020年 / 165卷 / 01期

基金：

日本学术振兴会;

关键词：

EXPERIMENTAL-INFECTION; WATER-BUFFALO; BLV PROVIRUS; CATTLE; SHEEP; TRANSMISSION; PROPAGATION; INTEGRATION; EXPRESSION; MORTALITY;

D O I：

10.1007/s00705-019-04474-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bovine leukemia virus (BLV) infects cattle worldwide and causes B-cell lymphoma in cattle. BLV has been identified in human breast and lung cancer and in blood, but the association of BLV and human cancer is controversial. In this study, we investigated the existence of BLV in 145 Japanese human blood cell lines and 54 human cancer cell lines, using a new highly sensitive PCR assay that can amplify even one copy of BLV using LTR primers different from those in previous studies on BLV provirus in breast cancer. All samples were found negative for BLV provirus, suggesting that BLV is unlikely to infect humans.

引用

页码：207 / 214

页数：8

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